Interleukin-28A Induces Epithelial Barrier Dysfunction in CD Patient-derived Intestinal Organoids

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Crohn’s disease patient-derived intestinal organoids were characterized by differentiation gene markers and then exposed to TNF-α, IFN-γ, IL-1β or LPS, or IL-28A with or without GLPG0634.
[American Journal of Physiology-Gastrointestinal and Liver Physiology]
Xu, P., Becker, H., Elizalde, M., Pierik, M., Masclee, A. A. M., & Jonkers, D. M. A. E. (2021). Interleukin-28A Induces Epithelial Barrier Dysfunction in CD Patient-derived Intestinal Organoids. American Journal of Physiology-Gastrointestinal and Liver Physiology. https://doi.org/10.1152/ajpgi.00064.2020 Cite
Abstract