BMP2-Dependent Gene Regulatory Network Analysis Reveals Klf4 as a Novel Transcription Factor of Osteoblast Differentiation

The BMP signaling pathway is widely regarded as one of the most important pathways in vertebrate skeletal biology, of which BMP2 is a potent inducer, governing the osteoblast differentiation of bone marrow stromal cells. Scientists used RNA-seq, ATAC-seq, and animal models to characterize the BMP2-dependent gene regulatory network governing osteoblast lineage commitment.