The authors report that the human mesenchymal stem cell (hMSC) secretome increased the proliferation of human granulosa cells (HGrC1). They showed by FACS analysis that treatment of HGrC1 cells with hMSC-conditioned media stimulated cellular proliferation.
[Scientific Reports]
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Park, H., Chugh, R. M., El Andaloussi, A., Hobeika, E., Esfandyari, S., Elsharoud, A., Ulin, M., Garcia, N., Bilal, M., & Al-Hendy, A. (2021). Human BM-MSC secretome enhances human granulosa cell proliferation and steroidogenesis and restores ovarian function in primary ovarian insufficiency mouse model. Scientific Reports, 11(1), 4525. https://doi.org/10.1038/s41598-021-84216-7 Cite