MAP3K2-Regulated Intestinal Stromal Cells Define a Distinct Stem Cell Niche

By
Justin.choi
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To determine the physiological role of MAP3K2-regulated intestinal stromal cells (MRISCs), scientists co-cultured MRISCs with colonic organoids and found that organoid growth was greater than when co-cultured with MRISC-depleted stromal cells
[Nature]
Wu, N., Sun, H., Zhao, X., Zhang, Y., Tan, J., Qi, Y., Wang, Q., Ng, M., Liu, Z., He, L., Niu, X., Chen, L., Liu, Z., Li, H.-B., Zeng, Y. A., Roulis, M., Liu, D., Cheng, J., Zhou, B., … Su, B. (2021). MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche. Nature, 1–5. https://doi.org/10.1038/s41586-021-03283-y Cite
Abstract