Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsThe effect of cigarette smoke extract on RANKL/RANK expression and that of exogenous RANKL on ubiquitin-proteasome pathway in C2C12 myotubes were investigated in vitro.
[American Journal of Respiratory Cell and Molecular Biology]
6445218 {6445218:PG93ENTV} apa 50 1 160003 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-c67b626076a34332091a1983f704b018%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22PG93ENTV%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Xiong%20et%20al.%22%2C%22parsedDate%22%3A%222021-03-09%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EXiong%2C%20J.%2C%20Le%2C%20Y.%2C%20Rao%2C%20Y.%2C%20Zhou%2C%20L.%2C%20Hu%2C%20Y.%2C%20Guo%2C%20S.%2C%20%26amp%3B%20Sun%2C%20Y.%20%282021%29.%20RANKL%20Mediates%20Muscle%20Atrophy%20and%20Dysfunction%20in%20a%20Cigarette%20Smoke-induced%20Model%20of%20COPD.%20%3Ci%3EAmerican%20Journal%20of%20Respiratory%20Cell%20and%20Molecular%20Biology%3C%5C%2Fi%3E.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1165%5C%2Frcmb.2020-0449OC%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1165%5C%2Frcmb.2020-0449OC%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3DPG93ENTV%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22RANKL%20Mediates%20Muscle%20Atrophy%20and%20Dysfunction%20in%20a%20Cigarette%20Smoke-induced%20Model%20of%20COPD%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jing%22%2C%22lastName%22%3A%22Xiong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yanqing%22%2C%22lastName%22%3A%22Le%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yafei%22%2C%22lastName%22%3A%22Rao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lu%22%2C%22lastName%22%3A%22Zhou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yuhan%22%2C%22lastName%22%3A%22Hu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Suliang%22%2C%22lastName%22%3A%22Guo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yongchang%22%2C%22lastName%22%3A%22Sun%22%7D%5D%2C%22abstractNote%22%3A%22Skeletal%20muscle%20dysfunction%20is%20one%20of%20the%20important%20comorbidities%20of%20COPD%2C%20however%20the%20underlying%20mechanisms%20remain%20largely%20unknown.%20RANKL%2C%20a%20key%20mediator%20in%20osteoclast%20differentiation%2C%20was%20also%20found%20to%20play%20a%20role%20in%20skeletal%20muscle%20pathogenesis.%20Whether%20RANKL%20is%20involved%20in%20COPD-related%20skeletal%20muscle%20dysfunction%20is%20yet%20unknown.%20We%20examined%20the%20expression%20of%20RANKL%5C%2FRANK%20in%20skeletal%20muscles%20from%20mice%20exposed%20to%20cigarette%20smoke%20%28CS%29%20for%2024%20weeks.%20Grip%20strength%20and%20exercise%20capacity%20as%20well%20as%20muscular%20morphology%20were%20evaluated%20in%20CS-exposed%20mice%20with%20or%20without%20anti-RANKL%20treatment.%20The%20expressions%20of%20protein-synthesis%20or%20muscle-growth%20related%20molecules%20%28IGF-1%2C%20myogenin%2C%20and%20myostatin%29%2C%20muscle%20specific%20ubiquitin%20E3%20ligases%20%28MuRF1%2C%20Atrogin1%29%2C%20and%20NF-%5Cu03bab%20inflammatory%20pathway%20were%20also%20evaluated%20in%20skeletal%20muscles.%20The%20effect%20of%20CS%20extract%20%28CSE%29%20on%20RANKL%5C%2FRANK%20expression%20and%20that%20of%20exogenous%20RANKL%20on%20ubiquitin-proteasome%20pathway%20in%20C2C12%20myotubes%20were%20investigated%20in%20vitro.%20Long-term%20CS%20exposure%20induced%20skeletal%20muscle%20dysfunction%20and%20atrophy%2C%20together%20with%20upregulation%20of%20RANKL%5C%2FRANK%20expressions%20in%20a%20well-established%20mouse%20model%20of%20COPD.%20RANKL%20neutralization%20prevented%20skeletal%20muscle%20dysfunction%20and%20atrophy.%20RANKL%20inhibition%20decreased%20expressions%20of%20myostatin%20and%20MuRF1%5C%2FAtrogin1%2C%20and%20suppressed%20NF-%5Cu03bab%20pathway%20in%20skeletal%20muscles%20from%20CS-exposed%20mice.%20In%20in%20vitro%20experiments%20with%20C2C12%20myotubes%2C%20CSE%20induced%20expression%20of%20RANKL%5C%2FRANK%2C%20and%20exogenous%20RANKL%20induced%20activation%20of%20ubiquitin-proteasome%20pathway%20and%20NF-%5Cu03bab%20pathway%20via%20RANK.%20Our%20results%20revealed%20an%20important%20role%20of%20the%20RANKL%5C%2FRANK%20pathway%20in%20muscle%20atrophy%20induced%20by%20CS%20exposure%2C%20suggesting%20that%20RANKL%20may%20be%20a%20potential%20therapeutic%20target%20in%20COPD-related%20skeletal%20muscle%20dysfunction.%22%2C%22date%22%3A%22March%209%2C%202021%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1165%5C%2Frcmb.2020-0449OC%22%2C%22ISSN%22%3A%221044-1549%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.atsjournals.org%5C%2Fdoi%5C%2F10.1165%5C%2Frcmb.2020-0449OC%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-03-12T05%3A56%3A26Z%22%7D%7D%5D%7D
Xiong, J., Le, Y., Rao, Y., Zhou, L., Hu, Y., Guo, S., & Sun, Y. (2021). RANKL Mediates Muscle Atrophy and Dysfunction in a Cigarette Smoke-induced Model of COPD. American Journal of Respiratory Cell and Molecular Biology. https://doi.org/10.1165/rcmb.2020-0449OC Cite
