Scientists confirmed that mind bomb 1 (MIB1) expression was elevated in pancreatic cancer tissues and that high levels of MIB associate with unfavorable prognosis. Overexpression of MIB1 enhanced proliferation and invasion of pancreatic cancer cells both in vitro and in vivo.
[Molecular Oncology]
6606345 {6606345:B73SE5TY} 1 apa 50 default 1 160838 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22B73SE5TY%22%2C%22library%22%3A%7B%22id%22%3A6606345%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zhang%20et%20al.%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BZhang%2C%20B.%2C%20Cheng%2C%20X.%2C%20Zhan%2C%20S.%2C%20Jin%2C%20X.%2C%20%26amp%3B%20Liu%2C%20T.%20%28n.d.%29.%20MIB1%20upregulates%20IQGAP1%20and%20promotes%20pancreatic%20cancer%20progression%20by%20inducing%20ST7%20degradation.%20%26lt%3Bi%26gt%3BMolecular%20Oncology%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3Bn%5C%2Fa%26lt%3B%5C%2Fi%26gt%3B%28n%5C%2Fa%29.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2Fhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2F1878-0261.12955%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2Fhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2F1878-0261.12955%26lt%3B%5C%2Fa%26gt%3B%20%26lt%3Ba%20title%3D%26%23039%3BCite%20in%20RIS%20Format%26%23039%3B%20class%3D%26%23039%3Bzp-CiteRIS%26%23039%3B%20data-zp-cite%3D%26%23039%3Bapi_user_id%3D6606345%26amp%3Bitem_key%3DB73SE5TY%26%23039%3B%20href%3D%26%23039%3Bjavascript%3Avoid%280%29%3B%26%23039%3B%26gt%3BCite%26lt%3B%5C%2Fa%26gt%3B%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22MIB1%20upregulates%20IQGAP1%20and%20promotes%20pancreatic%20cancer%20progression%20by%20inducing%20ST7%20degradation%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bin%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiang%22%2C%22lastName%22%3A%22Cheng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sudong%22%2C%22lastName%22%3A%22Zhan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xin%22%2C%22lastName%22%3A%22Jin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tao%22%2C%22lastName%22%3A%22Liu%22%7D%5D%2C%22abstractNote%22%3A%22Despite%20recent%20progress%20in%20cancer%20treatment%2C%20the%20prognosis%20of%20patients%20with%20pancreatic%20cancer%20still%20remains%20poor.%20Pancreatic%20tumors%20are%20reported%20to%20display%20high%20molecular%20heterogeneity.%20Elucidating%20the%20molecular%20mechanisms%20underlying%20pancreatic%20cancer%20progression%20is%20essential%20for%20improving%20patient%20treatment%20and%20survival.%20The%20overexpression%20of%20E3%20ubiquitin%20ligase%20Mind%20Bomb%201%20%28MIB1%29%20was%20previously%20described%20in%20pancreatic%20cancer%20cells%2C%20where%20it%20enhanced%20tumour%20cell%20proliferation.%20However%2C%20the%20role%20of%20MIB1%20in%20pancreatic%20cancer%20progression%20remains%20elusive.%20In%20the%20present%20study%2C%20we%20confirmed%20that%20MIB1%20expression%20is%20elevated%20in%20pancreatic%20cancer%20tissues%20and%20that%20high%20levels%20of%20MIB%20associate%20with%20unfavorable%20prognosis.%20Overexpression%20of%20MIB1%20enhanced%20proliferation%20and%20invasion%20of%20pancreatic%20cancer%20cells%20both%20in%20vitro%20and%20in%20vivo.%20We%20further%20investigated%20the%20molecular%20mechanisms%20downstream%20of%20MIB1%20and%20observed%20for%20the%20first%20time%20that%20MIB1%20targets%20ST7%2C%20previously%20described%20as%20suppressor%20of%20tumorigenicity%2C%20for%20proteasomal%20degradation.%20Furthermore%2C%20we%20found%20that%20ST7%20suppressed%20tumor%20growth%20by%20downregulating%20IQGAP1%20in%20pancreatic%20tumor%20cells.%20Thus%2C%20these%20data%20show%20that%20MIB1%20promotes%20pancreatic%20cancer%20progression%20by%20inducing%20ST7%20degradation%20followed%20by%20downregulation%20of%20IQGAP1%20in%20pancreatic%20cancer%20cells.%20In%20conclusion%2C%20our%20research%20shows%20that%20the%20MIB1%5C%2FST7%5C%2FIQGAP1%20axis%20is%20essential%20for%20pancreatic%20cancer%20progression%2C%20and%20MIB1%20inhibition%20may%20serve%20as%20a%20novel%20therapeutic%20strategy%20in%20patients%20with%20pancreatic%20cancer.%22%2C%22date%22%3A%22%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2F1878-0261.12955%22%2C%22ISSN%22%3A%221878-0261%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Ffebs.onlinelibrary.wiley.com%5C%2Fdoi%5C%2Fabs%5C%2F10.1002%5C%2F1878-0261.12955%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-04-06T15%3A19%3A59Z%22%7D%7D%5D%7D
Zhang, B., Cheng, X., Zhan, S., Jin, X., & Liu, T. (n.d.). MIB1 upregulates IQGAP1 and promotes pancreatic cancer progression by inducing ST7 degradation. Molecular Oncology, n/a(n/a). https://doi.org/https://doi.org/10.1002/1878-0261.12955 Cite