Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsScientists confirmed that mind bomb 1 (MIB1) expression was elevated in pancreatic cancer tissues and that high levels of MIB associate with unfavorable prognosis. Overexpression of MIB1 enhanced proliferation and invasion of pancreatic cancer cells both in vitro and in vivo.
[Molecular Oncology]
6606345 {6606345:B73SE5TY} apa 50 1 160838 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-ec5ad1f4941b1109aef7abc661b18830%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22B73SE5TY%22%2C%22library%22%3A%7B%22id%22%3A6606345%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zhang%20et%20al.%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EZhang%2C%20B.%2C%20Cheng%2C%20X.%2C%20Zhan%2C%20S.%2C%20Jin%2C%20X.%2C%20%26amp%3B%20Liu%2C%20T.%20%28n.d.%29.%20MIB1%20upregulates%20IQGAP1%20and%20promotes%20pancreatic%20cancer%20progression%20by%20inducing%20ST7%20degradation.%20%3Ci%3EMolecular%20Oncology%3C%5C%2Fi%3E%2C%20%3Ci%3En%5C%2Fa%3C%5C%2Fi%3E%28n%5C%2Fa%29.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2Fhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2F1878-0261.12955%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2Fhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2F1878-0261.12955%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6606345%26amp%3Bitem_key%3DB73SE5TY%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22MIB1%20upregulates%20IQGAP1%20and%20promotes%20pancreatic%20cancer%20progression%20by%20inducing%20ST7%20degradation%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bin%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiang%22%2C%22lastName%22%3A%22Cheng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sudong%22%2C%22lastName%22%3A%22Zhan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xin%22%2C%22lastName%22%3A%22Jin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tao%22%2C%22lastName%22%3A%22Liu%22%7D%5D%2C%22abstractNote%22%3A%22Despite%20recent%20progress%20in%20cancer%20treatment%2C%20the%20prognosis%20of%20patients%20with%20pancreatic%20cancer%20still%20remains%20poor.%20Pancreatic%20tumors%20are%20reported%20to%20display%20high%20molecular%20heterogeneity.%20Elucidating%20the%20molecular%20mechanisms%20underlying%20pancreatic%20cancer%20progression%20is%20essential%20for%20improving%20patient%20treatment%20and%20survival.%20The%20overexpression%20of%20E3%20ubiquitin%20ligase%20Mind%20Bomb%201%20%28MIB1%29%20was%20previously%20described%20in%20pancreatic%20cancer%20cells%2C%20where%20it%20enhanced%20tumour%20cell%20proliferation.%20However%2C%20the%20role%20of%20MIB1%20in%20pancreatic%20cancer%20progression%20remains%20elusive.%20In%20the%20present%20study%2C%20we%20confirmed%20that%20MIB1%20expression%20is%20elevated%20in%20pancreatic%20cancer%20tissues%20and%20that%20high%20levels%20of%20MIB%20associate%20with%20unfavorable%20prognosis.%20Overexpression%20of%20MIB1%20enhanced%20proliferation%20and%20invasion%20of%20pancreatic%20cancer%20cells%20both%20in%20vitro%20and%20in%20vivo.%20We%20further%20investigated%20the%20molecular%20mechanisms%20downstream%20of%20MIB1%20and%20observed%20for%20the%20first%20time%20that%20MIB1%20targets%20ST7%2C%20previously%20described%20as%20suppressor%20of%20tumorigenicity%2C%20for%20proteasomal%20degradation.%20Furthermore%2C%20we%20found%20that%20ST7%20suppressed%20tumor%20growth%20by%20downregulating%20IQGAP1%20in%20pancreatic%20tumor%20cells.%20Thus%2C%20these%20data%20show%20that%20MIB1%20promotes%20pancreatic%20cancer%20progression%20by%20inducing%20ST7%20degradation%20followed%20by%20downregulation%20of%20IQGAP1%20in%20pancreatic%20cancer%20cells.%20In%20conclusion%2C%20our%20research%20shows%20that%20the%20MIB1%5C%2FST7%5C%2FIQGAP1%20axis%20is%20essential%20for%20pancreatic%20cancer%20progression%2C%20and%20MIB1%20inhibition%20may%20serve%20as%20a%20novel%20therapeutic%20strategy%20in%20patients%20with%20pancreatic%20cancer.%22%2C%22date%22%3A%22%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2F1878-0261.12955%22%2C%22ISSN%22%3A%221878-0261%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Ffebs.onlinelibrary.wiley.com%5C%2Fdoi%5C%2Fabs%5C%2F10.1002%5C%2F1878-0261.12955%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-04-06T15%3A19%3A59Z%22%7D%7D%5D%7D
Zhang, B., Cheng, X., Zhan, S., Jin, X., & Liu, T. (n.d.). MIB1 upregulates IQGAP1 and promotes pancreatic cancer progression by inducing ST7 degradation. Molecular Oncology, n/a(n/a). https://doi.org/https://doi.org/10.1002/1878-0261.12955 Cite
