Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsGene knockdown of NADH dehydrogenase [ubiquinone] 1 alpha subcomplex, 4-like 2 (NDUFA4L2) inhibited tumor cell proliferation and enhanced apoptosis, while tumor cells initiated protective mitophagy in vitro and in vivo.
[Cell Death & Disease]
6807162 {6807162:56NDBQDE} apa 50 1 160929 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-582cd3c244a1ae0db7780871a2ccaac2%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%2256NDBQDE%22%2C%22library%22%3A%7B%22id%22%3A6807162%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Chen%20et%20al.%22%2C%22parsedDate%22%3A%222021-04-07%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EChen%2C%20Z.%2C%20Wei%2C%20X.%2C%20Wang%2C%20X.%2C%20Zheng%2C%20X.%2C%20Chang%2C%20B.%2C%20Shen%2C%20L.%2C%20Zhu%2C%20H.%2C%20Yang%2C%20M.%2C%20Li%2C%20S.%2C%20%26amp%3B%20Zheng%2C%20X.%20%282021%29.%20NDUFA4L2%20promotes%20glioblastoma%20progression%2C%20is%20associated%20with%20poor%20survival%2C%20and%20can%20be%20effectively%20targeted%20by%20apatinib.%20%3Ci%3ECell%20Death%20%26amp%3B%20Disease%3C%5C%2Fi%3E%2C%20%3Ci%3E12%3C%5C%2Fi%3E%284%29%2C%201%26%23x2013%3B15.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41419-021-03646-3%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41419-021-03646-3%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6807162%26amp%3Bitem_key%3D56NDBQDE%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22NDUFA4L2%20promotes%20glioblastoma%20progression%2C%20is%20associated%20with%20poor%20survival%2C%20and%20can%20be%20effectively%20targeted%20by%20apatinib%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zheng%22%2C%22lastName%22%3A%22Chen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiangyu%22%2C%22lastName%22%3A%22Wei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xueyi%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xuan%22%2C%22lastName%22%3A%22Zheng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bowen%22%2C%22lastName%22%3A%22Chang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lin%22%2C%22lastName%22%3A%22Shen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hanshuo%22%2C%22lastName%22%3A%22Zhu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Min%22%2C%22lastName%22%3A%22Yang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shiting%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xuesheng%22%2C%22lastName%22%3A%22Zheng%22%7D%5D%2C%22abstractNote%22%3A%22NADH%20dehydrogenase%20%5Bubiquinone%5D%201%20alpha%20subcomplex%2C%204-like%202%20%28NDUFA4L2%29%20is%20a%20subunit%20of%20Complex%20I%20of%20the%20mitochondrial%20respiratory%20chain%2C%20which%20is%20important%20in%20metabolic%20reprogramming%20and%20oxidative%20stress%20in%20multiple%20cancers.%20However%2C%20the%20biological%20role%20and%20molecular%20regulation%20of%20NDUFA4L2%20in%20glioblastoma%20%28GBM%29%20are%20poorly%20understood.%20Here%2C%20we%20found%20that%20NDUFA4L2%20was%20significantly%20upregulated%20in%20GBM%3B%20the%20elevated%20levels%20were%20correlated%20with%20reduced%20patient%20survival.%20Gene%20knockdown%20of%20NDUFA4L2%20inhibited%20tumor%20cell%20proliferation%20and%20enhanced%20apoptosis%2C%20while%20tumor%20cells%20initiated%20protective%20mitophagy%20in%20vitro%20and%20in%20vivo.%20We%20used%20lentivirus%20to%20reduce%20expression%20levels%20of%20NDUFA4L2%20protein%20in%20GBM%20cells%20exposed%20to%20mitophagy%20blockers%2C%20which%20led%20to%20a%20significant%20enhancement%20of%20tumor%20cell%20apoptosis%20in%20vitro%20and%20inhibited%20the%20development%20of%20xenografted%20tumors%20in%20vivo.%20In%20contrast%20to%20other%20tumor%20types%2C%20NDUFA4L2%20expression%20in%20GBM%20may%20not%20be%20directly%20regulated%20by%20hypoxia-inducible%20factor%20%28HIF%29-1%5Cu03b1%2C%20because%20HIF-1%5Cu03b1%20inhibitors%20failed%20to%20inhibit%20NDUFA4L2%20in%20GBM.%20Apatinib%20was%20able%20to%20effectively%20target%20NDUFA4L2%20in%20GBM%2C%20presenting%20an%20alternative%20to%20the%20use%20of%20lentiviruses%2C%20which%20currently%20cannot%20be%20used%20in%20humans.%20Taken%20together%2C%20our%20data%20suggest%20the%20use%20of%20NDUFA4L2%20as%20a%20potential%20therapeutic%20target%20in%20GBM%20and%20demonstrate%20a%20practical%20treatment%20approach.%22%2C%22date%22%3A%222021-04-07%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41419-021-03646-3%22%2C%22ISSN%22%3A%222041-4889%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41419-021-03646-3%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-04-07T17%3A02%3A36Z%22%7D%7D%5D%7D
Chen, Z., Wei, X., Wang, X., Zheng, X., Chang, B., Shen, L., Zhu, H., Yang, M., Li, S., & Zheng, X. (2021). NDUFA4L2 promotes glioblastoma progression, is associated with poor survival, and can be effectively targeted by apatinib. Cell Death & Disease, 12(4), 1–15. https://doi.org/10.1038/s41419-021-03646-3 Cite
