Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsThe authors examined the regulatory effect of circular RNA HIPK3 (circHIPK3) during myocardial ischemia/reperfusion and investigated its mechanism in cardiomyocyte autophagy and apoptosis.
[Cell Death Discovery]
6606345 {6606345:UU8P6YWJ} apa 50 1 161096 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-706fc7346cdd9a3ab8c6c668c6a14076%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22UU8P6YWJ%22%2C%22library%22%3A%7B%22id%22%3A6606345%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Qiu%20et%20al.%22%2C%22parsedDate%22%3A%222021-04-06%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EQiu%2C%20Z.%2C%20Wang%2C%20Y.%2C%20Liu%2C%20W.%2C%20Li%2C%20C.%2C%20Zhao%2C%20R.%2C%20Long%2C%20X.%2C%20Rong%2C%20J.%2C%20Deng%2C%20W.%2C%20Shen%2C%20C.%2C%20Yuan%2C%20J.%2C%20Chen%2C%20W.%2C%20%26amp%3B%20Shi%2C%20B.%20%282021%29.%20CircHIPK3%20regulates%20the%20autophagy%20and%20apoptosis%20of%20hypoxia%5C%2Freoxygenation-stimulated%20cardiomyocytes%20via%20the%20miR-20b-5p%5C%2FATG7%20axis.%20%3Ci%3ECell%20Death%20Discovery%3C%5C%2Fi%3E%2C%20%3Ci%3E7%3C%5C%2Fi%3E%281%29%2C%201%26%23x2013%3B12.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41420-021-00448-6%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41420-021-00448-6%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6606345%26amp%3Bitem_key%3DUU8P6YWJ%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22CircHIPK3%20regulates%20the%20autophagy%20and%20apoptosis%20of%20hypoxia%5C%2Freoxygenation-stimulated%20cardiomyocytes%20via%20the%20miR-20b-5p%5C%2FATG7%20axis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhimei%22%2C%22lastName%22%3A%22Qiu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yan%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Weiwei%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chaofu%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ranzun%22%2C%22lastName%22%3A%22Zhao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xianping%22%2C%22lastName%22%3A%22Long%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jidong%22%2C%22lastName%22%3A%22Rong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wengweng%22%2C%22lastName%22%3A%22Deng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Changyin%22%2C%22lastName%22%3A%22Shen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jinson%22%2C%22lastName%22%3A%22Yuan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wengming%22%2C%22lastName%22%3A%22Chen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bei%22%2C%22lastName%22%3A%22Shi%22%7D%5D%2C%22abstractNote%22%3A%22Autophagy%20and%20apoptosis%20are%20involved%20in%20myocardial%20ischemia%5C%2Freperfusion%20%28I%5C%2FR%29%20injury.%20Research%20indicates%20that%20circular%20RNA%20HIPK3%20%28circHIPK3%29%20is%20crucial%20to%20cell%20autophagy%20and%20apoptosis%20in%20various%20cancer%20types.%20However%2C%20the%20role%20of%20circHIPK3%20in%20the%20regulation%20of%20cardiomyocyte%20autophagy%20and%20apoptosis%20during%20I%5C%2FR%20remains%20unknown.%20Our%20study%20aimed%20to%20examine%20the%20regulatory%20effect%20of%20circHIPK3%20during%20myocardial%20I%5C%2FR%20and%20investigate%20its%20mechanism%20in%20cardiomyocyte%20autophagy%20and%20apoptosis.%20Methods%20and%20results.%20The%20expression%20of%20circHIPK3%20was%20upregulated%20during%20myocardial%20I%5C%2FR%20injury%20and%20hypoxia%5C%2Freoxygenation%20%28H%5C%2FR%29%20injury%20of%20cardiomyocytes.%20To%20study%20the%20potential%20role%20of%20circHIPK3%20in%20myocardial%20H%5C%2FR%20injury%2C%20we%20performed%20gain-of-function%20and%20loss-of-function%20analyses%20of%20circHIPK3%20in%20cardiomyocytes.%20Overexpression%20of%20circHIPK3%20significantly%20promoted%20H%5C%2FR-induced%20cardiomyocyte%20autophagy%20and%20cell%20injury%20%28increased%20intracellular%20reactive%20oxygen%20species%20%28ROS%29%20and%20apoptosis%29%20compared%20to%20those%20in%20the%20control%20group%2C%20while%20silencing%20of%20circHIPK3%20showed%20the%20opposite%20effect.%20Further%20research%20found%20that%20circHIPK3%20acted%20as%20an%20endogenous%20miR-20b-5p%20sponge%20to%20sequester%20and%20inhibit%20miR-20b-5p%20activity%2C%20resulting%20in%20increased%20ATG7%20expression.%20In%20addition%2C%20miR-20b-5p%20inhibitors%20reversed%20the%20decrease%20in%20ATG7%20induced%20by%20silencing%20circHIPK3.%20Conclusions.%20CircHIPK3%20can%20accelerate%20cardiomyocyte%20autophagy%20and%20apoptosis%20during%20myocardial%20I%5C%2FR%20injury%20through%20the%20miR-20b-5p%5C%2FATG7%20axis.%20These%20data%20suggest%20that%20circHIPK3%20may%20serve%20as%20a%20potential%20therapeutic%20target%20for%20I%5C%2FR.%22%2C%22date%22%3A%222021-04-06%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41420-021-00448-6%22%2C%22ISSN%22%3A%222058-7716%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41420-021-00448-6%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-04-12T22%3A26%3A04Z%22%7D%7D%5D%7D
Qiu, Z., Wang, Y., Liu, W., Li, C., Zhao, R., Long, X., Rong, J., Deng, W., Shen, C., Yuan, J., Chen, W., & Shi, B. (2021). CircHIPK3 regulates the autophagy and apoptosis of hypoxia/reoxygenation-stimulated cardiomyocytes via the miR-20b-5p/ATG7 axis. Cell Death Discovery, 7(1), 1–12. https://doi.org/10.1038/s41420-021-00448-6 Cite
