Meningeal Lymphatics Affect Microglia Responses and Anti-Aβ Immunotherapy

By
Justin.choi
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Investigators showed that ablation of meningeal lymphatic vessels in 5xFAD mice (a mouse model of amyloid deposition that expressed five mutations found in familial Alzheimer’s disease) worsened the outcome of mice treated with anti-Aβ passive immunotherapy.
[Nature]
Da Mesquita, S., Papadopoulos, Z., Dykstra, T., Brase, L., Farias, F. G., Wall, M., Jiang, H., Kodira, C. D., de Lima, K. A., Herz, J., Louveau, A., Goldman, D. H., Salvador, A. F., Onengut-Gumuscu, S., Farber, E., Dabhi, N., Kennedy, T., Milam, M. G., Baker, W., … Kipnis, J. (2021). Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy. Nature, 1–6. https://doi.org/10.1038/s41586-021-03489-0 Cite
Abstract