Mastocytosis-Derived Extracellular Vesicles Deliver miR-23a and miR-30a Into Pre-Osteoblasts and Prevent Osteoblastogenesis and Bone Formation

Researchers found that extracellular vesicles released by neoplastic mast cells and present in the serum of patients with systemic mastocytosis blocked osteoblast differentiation and mineralization in culture, and when injected into mice diminished the expression of osteoblast markers, and trabecular bone volume and microarchitecture.