Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsLinear, adhered rat and human 3D neuronal-astrocyte cultures were developed to enable the study of aggregation and sorting of these cells. An in silico model of the contraction, clustering, and cell sorting in the 3D cultures was also developed.
[Communications Biology]
7753456 A2Q9GCHX items 1 apa 0 default asc 1 162406 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-1224dfbbdaa3250b0a1138d41a981e0f%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22A2Q9GCHX%22%2C%22library%22%3A%7B%22id%22%3A7753456%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hasan%20and%20Berdichevsky%22%2C%22parsedDate%22%3A%222021-05-17%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EHasan%2C%20M.%20F.%2C%20%26amp%3B%20Berdichevsky%2C%20Y.%20%282021%29.%20Neuron%20and%20astrocyte%20aggregation%20and%20sorting%20in%20three-dimensional%20neuronal%20constructs.%20%3Ci%3ECommunications%20Biology%3C%5C%2Fi%3E%2C%20%3Ci%3E4%3C%5C%2Fi%3E%281%29%2C%201%26%23x2013%3B16.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs42003-021-02104-2%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs42003-021-02104-2%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D7753456%26amp%3Bitem_key%3DA2Q9GCHX%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Neuron%20and%20astrocyte%20aggregation%20and%20sorting%20in%20three-dimensional%20neuronal%20constructs%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Md%20Fayad%22%2C%22lastName%22%3A%22Hasan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yevgeny%22%2C%22lastName%22%3A%22Berdichevsky%22%7D%5D%2C%22abstractNote%22%3A%22Aggregation%20and%20self-sorting%20of%20cells%20in%20three%20dimensional%20cultures%20have%20been%20described%20for%20non-neuronal%20cells.%20Despite%20increased%20interest%20in%20engineered%20neural%20tissues%20for%20treating%20brain%20injury%20or%20for%20modeling%20neurological%20disorders%20in%20vitro%2C%20little%20data%20is%20available%20on%20collective%20cell%20movements%20in%20neuronal%20aggregates.%20Migration%20and%20sorting%20of%20cells%20may%20alter%20these%20constructs%5Cu2019%20morphology%20and%2C%20therefore%2C%20the%20function%20of%20their%20neural%20circuitry.%20In%20this%20work%2C%20linear%2C%20adhered%20rat%20and%20human%203D%20neuronal-astrocyte%20cultures%20were%20developed%20to%20enable%20the%20study%20of%20aggregation%20and%20sorting%20of%20these%20cells.%20An%20in%20silico%20model%20of%20the%20contraction%2C%20clustering%2C%20and%20cell%20sorting%20in%20the%203D%20cultures%20was%20also%20developed.%20Experiments%20and%20computational%20modeling%20showed%20that%20aggregation%20was%20mainly%20a%20neuron%20mediated%20process%2C%20and%20formation%20of%20astrocyte-rich%20sheaths%20in%203D%20cultures%20depended%20on%20differential%20attraction%20between%20neurons%20and%20astrocytes.%20In%20silico%20model%20predicted%20formation%20of%20self-assembled%20neuronal%20layers%20in%20disk-shaped%203D%20cultures.%20Neuronal%20activity%20patterns%20were%20found%20to%20correlate%20with%20local%20morphological%20differences.%20This%20model%20of%20neuronal%20and%20astrocyte%20aggregation%20and%20sorting%20may%20benefit%20future%20design%20of%20neuronal%20constructs.%22%2C%22date%22%3A%222021-05-17%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs42003-021-02104-2%22%2C%22ISSN%22%3A%222399-3642%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs42003-021-02104-2%22%2C%22deleted%22%3A1%2C%22collections%22%3A%5B%22TUURQW3H%22%5D%2C%22dateModified%22%3A%222021-05-17T21%3A46%3A00Z%22%7D%7D%5D%7D
Hasan, M. F., & Berdichevsky, Y. (2021). Neuron and astrocyte aggregation and sorting in three-dimensional neuronal constructs. Communications Biology, 4(1), 1–16. https://doi.org/10.1038/s42003-021-02104-2 Cite
