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Pulmonary Cell NewsGenetic silencing of MDA-9/Syntenin or treatment with a pharmacological inhibitor of the PDZ1 domain, PDZ1i, activated the immune system to kill cancer cells.
[Proceedings of the National Academy of Sciences of the United States of America]
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Pradhan, A. K., Maji, S., Bhoopathi, P., Talukdar, S., Mannangatti, P., Guo, C., Wang, X.-Y., Cartagena, L. C., Idowu, M., Landry, J. W., Sarkar, D., Emdad, L., Cavenee, W. K., Das, S. K., & Fisher, P. B. (2021). Pharmacological inhibition of MDA-9/Syntenin blocks breast cancer metastasis through suppression of IL-1β. Proceedings of the National Academy of Sciences, 118(21). https://doi.org/10.1073/pnas.2103180118 Cite
