KEAP1 Deficiency Drives Glucose Dependency and Sensitizes Lung Cancer Cells and Tumors to GLUT Inhibition

By
Justin.choi
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Investigators showed that KEAP1 deficiency promotes glucose dependency in lung cancer cells, and KEAP1-mutant/deficient lung cancer cells were more vulnerable to glucose deprivation than their WT counterparts.
[iScience]
Koppula, P., Olszewski, K., Zhang, Y., Kondiparthi, L., Liu, X., Lei, G., Das, M., Fang, B., Poyurovsky, M. V., & Gan, B. (2021). KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition. IScience, 0(0). https://doi.org/10.1016/j.isci.2021.102649 Cite
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