Investigators demonstrated that melanocortin-1 receptor (MC1R) is a critical factor in chromosome stability and centromere integrity in melanocytes. α-MSH/MC1R stimulation prevents melanocytes from UV radiation-induced damage of chromosome stability and centromere integrity.
[Cell Death Discovery]
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Li, X., Mao, W., Chen, J., Goding, C. R., Cui, R., Xu, Z.-X., & Miao, X. (2021). The protective role of MC1R in chromosome stability and centromeric integrity in melanocytes. Cell Death Discovery, 7(1), 1–9. https://doi.org/10.1038/s41420-021-00499-9 Cite