SPOP and OTUD7A Control EWS–FLI1 Protein Stability to Govern Ewing Sarcoma Growth

Speckle-type POZ protein (SPOP) and OTU domain-containing protein 7A (OTUD7A) are identified as the bona fide E3 ligase and deubiquitinase, respectively, that control Ewing sarcoma breakpoint region 1-Friend leukemia integration 1 (EWS–FLI1) protein turnover in Ewing sarcoma.