Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsFocal cerebral ischemia-reperfusion injury model and primary cortical neurons were established an oxygen-glucose deprivation injury model. Neuronal cell viability was determined by MTT assay. Western blot analysis was determined for protein expression.
[Brain and Behavior]
7753456 9HXR3I6M items 1 apa 0 default asc 1 163240 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-c26f86177675c71d24e40ecf823c877f%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%229HXR3I6M%22%2C%22library%22%3A%7B%22id%22%3A7753456%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Xue%20et%20al.%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EXue%2C%20Z.%2C%20Zhao%2C%20K.%2C%20Sun%2C%20Z.%2C%20Wu%2C%20C.%2C%20Yu%2C%20B.%2C%20Kong%2C%20D.%2C%20%26amp%3B%20Xu%2C%20B.%20%28n.d.%29.%20Isorhapontigenin%20ameliorates%20cerebral%20ischemia%5C%2Freperfusion%20injury%20via%20modulating%20Kinase%20C%26%23x3B5%3B%5C%2FNrf2%5C%2FHO-1%20signaling%20pathway.%20%3Ci%3EBrain%20and%20Behavior%3C%5C%2Fi%3E%2C%20%3Ci%3En%5C%2Fa%3C%5C%2Fi%3E%28n%5C%2Fa%29%2C%20e02143.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2Fhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fbrb3.2143%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2Fhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fbrb3.2143%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D7753456%26amp%3Bitem_key%3D9HXR3I6M%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Isorhapontigenin%20ameliorates%20cerebral%20ischemia%5C%2Freperfusion%20injury%20via%20modulating%20Kinase%20C%5Cu03b5%5C%2FNrf2%5C%2FHO-1%20signaling%20pathway%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhe%22%2C%22lastName%22%3A%22Xue%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kai%22%2C%22lastName%22%3A%22Zhao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhenghui%22%2C%22lastName%22%3A%22Sun%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chen%22%2C%22lastName%22%3A%22Wu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bowen%22%2C%22lastName%22%3A%22Yu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dongsheng%22%2C%22lastName%22%3A%22Kong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bainan%22%2C%22lastName%22%3A%22Xu%22%7D%5D%2C%22abstractNote%22%3A%22Background%20Isorhapontigenin%20%28ISO%29%20has%20been%20shown%20to%20have%20antioxidant%20activity.%20This%20study%20aimed%20to%20investigate%20the%20antioxidant%20effects%20of%20ISO%20on%20cerebral%20ischemia%5C%2Freperfusion%20%28I%5C%2FR%29%20injury%20and%20its%20possible%20molecular%20mechanisms.%20Methods%20Focal%20cerebral%20ischemia-reperfusion%20injury%20%28MCAO%5C%2FR%29%20model%20and%20primary%20cortical%20neurons%20were%20established%20an%20oxygen-glucose%20deprivation%20%28OGD%20%5C%2F%20R%29%20injury%20model.%20After%2024%20hr%20of%20reperfusion%2C%20the%20neurological%20deficits%20of%20the%20rats%20were%20analyzed%20and%20HE%20staining%20was%20performed%2C%20and%20the%20infarct%20volume%20was%20calculated%20by%20TTC%20staining.%20In%20addition%2C%20the%20reactive%20oxygen%20species%20%28ROS%29%20in%20rat%20brain%20tissue%2C%20the%20content%20of%204-Hydroxynonenal%20%284-HNE%29%2C%20and%208-hydroxy2deoxyguanosine%20%288-OHdG%29%20were%20detected.%20Neuronal%20cell%20viability%20was%20determined%20by%20MTT%20assay.%20Western%20blot%20analysis%20was%20determined%20for%20protein%20expression.%20Results%20ISO%20treatment%20significantly%20improved%20neurological%20scores%2C%20reduced%20infarct%20volume%2C%20necrotic%20neurons%2C%20ROS%20production%2C%204-HNE%2C%20and%208-OHdG%20levels.%20At%20the%20same%20time%2C%20ISO%20significantly%20increased%20the%20expression%20of%20Nrf2%20and%20HO-1.%20The%20neuroprotective%20effects%20of%20ISO%20can%20be%20eliminated%20by%20knocking%20down%20Nrf2%20and%20HO-1.%20In%20addition%2C%20knockdown%20of%20the%20PKC%5Cu03b5%20blocked%20ISO-induced%20nuclear%20Nfr2%2C%20HO-1%20expression.%20Conclusion%20ISO%20protected%20against%20oxidative%20damage%20induced%20by%20brain%20I%5C%2FR%2C%20and%20its%20neuroprotective%20mechanism%20may%20be%20related%20to%20the%20PKC%5Cu03b5%5C%2FNrf2%5C%2FHO-1%20pathway.%22%2C%22date%22%3A%22%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fbrb3.2143%22%2C%22ISSN%22%3A%222162-3279%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fonlinelibrary.wiley.com%5C%2Fdoi%5C%2Fabs%5C%2F10.1002%5C%2Fbrb3.2143%22%2C%22deleted%22%3A1%2C%22collections%22%3A%5B%22TUURQW3H%22%5D%2C%22dateModified%22%3A%222021-06-09T20%3A08%3A26Z%22%7D%7D%5D%7D
Xue, Z., Zhao, K., Sun, Z., Wu, C., Yu, B., Kong, D., & Xu, B. (n.d.). Isorhapontigenin ameliorates cerebral ischemia/reperfusion injury via modulating Kinase Cε/Nrf2/HO-1 signaling pathway. Brain and Behavior, n/a(n/a), e02143. https://doi.org/https://doi.org/10.1002/brb3.2143 Cite
