Cellular Reprogramming of Diabetic Foot Ulcer Fibroblasts Triggers Pro-healing miRNA-Mediated Epigenetic Signature

Investigators found that let-7c, miR-26b-5p, −29c-3p, −148a-3p, −196a-5p, −199b-5p and −374a-5p were suppressed in iPSC-derived fibroblasts in vitro and in 3D dermis-like self-assembly tissue, whereas their corresponding targets involved in cellular migration were upregulated.