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Pulmonary Cell NewsInvestigators examined the upstream signaling pathways that control Tim-3–mediated increases in phosphorylated S6 in T cells. They defined the localization of Tim-3 relative to the T cell immune synapse and its effects on downstream signaling.
[Science Signaling]
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Kataoka, S., Manandhar, P., Lee, J., Workman, C. J., Banerjee, H., Szymczak-Workman, A. L., Kvorjak, M., Lohmueller, J., & Kane, L. P. (2021). The costimulatory activity of Tim-3 requires Akt and MAPK signaling and its recruitment to the immune synapse. Science Signaling, 14(687). https://doi.org/10.1126/scisignal.aba0717 Cite
