Reserachers showed inhibition of glucose metabolism with low dose 2-deoxyglucose in combination with a MEK inhibitor induced apoptosis in KrasG12D-driven pancreatic ductal adenocarcinoma cells in vitro.
[Cancer Research]
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Yan, L., Tu, B., Yao, J., Gong, J., Carugo, A., Bristow, C. A., Wang, Q., Zhu, C., Dai, B., Kang, Y., Han, L., Feng, N., Jin, Y., Fleming, J., Heffernan, T. P., Yao, W., & Ying, H. (2021). Targeting glucose metabolism sensitizes pancreatic cancer to MEK inhibition. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-3792 Cite
