The lncRNA ‘UCA1’ Modulates the Response to Chemotherapy of Ovarian Cancer through Direct Binding to miR-27a-5p and Control of UBE2N Levels

By
Justin.choi
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The authors observed that UCA1 a lncRNA previously reported to play an oncogenic role in several malignancies, is overexpressed in the chemoresistant ovarian cancer cell line OAW42-R compared to their chemotherapy sensitive counterpart OAW42.
[Molecular Oncology]
Wambecke, A., Ahmad, M., Morice, P.-M., Lambert, B., Weiswald, L.-B., Vernon, M., Vigneron, N., Abeilard, E., Brotin, E., Figeac, M., Gauduchon, P., Poulain, L., Denoyelle, C., & Meryet-Figuiere, M. (n.d.). The lncRNA ‘UCA1’ modulates the response to chemotherapy of ovarian cancer through direct binding to miR-27a-5p and control of UBE2N levels. Molecular Oncology, n/a(n/a). https://doi.org/10.1002/1878-0261.13045 Cite
Abstract