YBX1 Is Required for Maintaining Myeloid Leukemia Cell Survival by Regulating BCL2 Stability in an m6A-Dependent Manner

Expression of YBX1 was significantly upregulated in myeloid leukemia cells, and deletion of YBX1 dramatically induced apoptosis and promoted differentiation coupled with reduced proliferation and impaired leukemic capacity of primary human and mouse acute myeloid leukemia cells in vitro and in vivo.