Smooth Muscle Cell–Enriched Long Noncoding RNA Regulates Cell Plasticity and Atherosclerosis by Interacting with Serum Response Factor

Scientists identified a vascular smooth muscle cell (VSMC)-enriched long noncoding RNA cardiac mesoderm enhancer-associated noncoding RNA (CARMN) that was dynamically regulated with progression of atherosclerosis. In both mouse and human atherosclerotic plaques, CARMN colocalized with VSMCs and was expressed in the nucleus.