Selective Activation of PFKL Suppresses the Phagocytic Oxidative Burst

Researchers used two unbiased chemical proteomic strategies to show that small-molecule LDC7559, or a more potent designed analog NA-11, inhibited the NOX2-dependent oxidative burst in neutrophils by activating the glycolytic enzyme phosphofructokinase-1 liver type and dampening flux through the pentose phosphate pathway.