Combination of Rapamycin and SAHA Enhanced Radiosensitization by Inducing Autophagy and Acetylation in NSCLC

Scientists investigated the effects of autophagy-inducing agent, Rapamycin, combined with the histone deacetylase inhibitor, Suberoylanilide Hydroxamic Acid, on the radiosensitivity of A549 and SK-MES-1 cells, and examined the combination effects on DNA damage repair, and determined the level of autophagy and acetylation in A549 cells.