Type I Collagen Promotes Tumor Progression of Integrin β1 Positive Gastric Cancer through a BCL9L/β-Catenin Signaling Pathway

In vitro, researchers found that 3D collagen culture promoted the capability of colony formation and growth in integrin β1 positive gastric cancer, whereas limited colony growth was observed in ITGB1 negative gastric cancer, suggesting the role of ITGB1 in type I collagen associated tumor progression.