Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsHuman dermal papilla cells, isolated fresh hair follicles, and mouse back skin were exposed with the non-thermal atmospheric pressure plasma. Biological outcomes were measured using RNA-sequencing, RT-PCR, Western blots, and immunostaining.
[Scientific Reports]
6445212 CH4FDBFN items 1 apa 0 default asc 1 165452 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-c3b0b722b08c8eb1e1def8bd5bf124f0%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22CH4FDBFN%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hwang%20et%20al.%22%2C%22parsedDate%22%3A%222021-08-09%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EHwang%2C%20J.-H.%2C%20Lee%2C%20H.-Y.%2C%20Chung%2C%20K.%20B.%2C%20Lee%2C%20H.%20J.%2C%20Kim%2C%20J.%2C%20Song%2C%20K.%2C%20%26amp%3B%20Kim%2C%20D.-Y.%20%282021%29.%20Non-thermal%20atmospheric%20pressure%20plasma%20activates%20Wnt%5C%2F%26%23x3B2%3B-catenin%20signaling%20in%20dermal%20papilla%20cells.%20%3Ci%3EScientific%20Reports%3C%5C%2Fi%3E%2C%20%3Ci%3E11%3C%5C%2Fi%3E%281%29%2C%2016125.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-021-95650-y%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-021-95650-y%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3DCH4FDBFN%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Non-thermal%20atmospheric%20pressure%20plasma%20activates%20Wnt%5C%2F%5Cu03b2-catenin%20signaling%20in%20dermal%20papilla%20cells%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ji-Hye%22%2C%22lastName%22%3A%22Hwang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hyun-Young%22%2C%22lastName%22%3A%22Lee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kyung%20Bae%22%2C%22lastName%22%3A%22Chung%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hae%20June%22%2C%22lastName%22%3A%22Lee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jino%22%2C%22lastName%22%3A%22Kim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kiwon%22%2C%22lastName%22%3A%22Song%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Do-Young%22%2C%22lastName%22%3A%22Kim%22%7D%5D%2C%22abstractNote%22%3A%22There%20is%20an%20unmet%20need%20for%20novel%2C%20non-pharmacological%20therapeutics%20to%20treat%20alopecia.%20Recent%20studies%20have%20shown%20the%20potential%20biological%20benefits%20of%20non-thermal%20atmospheric%20pressure%20plasma%20%28NTAPP%29%2C%20including%20wound%20healing%2C%20angiogenesis%2C%20and%20the%20proliferation%20of%20stem%20cells.%20We%20hypothesized%20that%20NTAPP%20might%20have%20a%20stimulatory%20effect%20on%20hair%20growth%20or%20regeneration.%20We%20designed%20an%20NTAPP-generating%20apparatus%20which%20is%20applicable%20to%20in%20vitro%20and%20in%20vivo%20experiments.%20The%20human%20dermal%20papilla%20%28DP%29%20cells%2C%20isolated%20fresh%20hair%20follicles%2C%20and%20mouse%20back%20skin%20were%20exposed%20with%20the%20NTAPP.%20Biological%20outcomes%20were%20measured%20using%20RNA-sequencing%2C%20RT-PCR%2C%20Western%20blots%2C%20and%20immunostaining.%20The%20NTAPP%20treatment%20increased%20the%20expression%20levels%20of%20Wnt%5C%2F%5Cu03b2-catenin%20pathway-related%20genes%20%28AMER3%2C%20CCND1%2C%20LEF1%2C%20and%20LRG1%29%20and%20proteins%20%28%5Cu03b2-catenin%2C%20p-GSK3%5Cu03b2%2C%20and%20cyclin%20D1%29%20in%20human%20DP%20cells.%20In%20contrast%2C%20inhibitors%20of%20Wnt%5C%2F%5Cu03b2-catenin%20signaling%2C%20endo-IWR1%20and%20IWP2%2C%20attenuated%20the%20levels%20of%20cyclin%20D1%2C%20p-GSK3%5Cu03b2%2C%20and%20%5Cu03b2-catenin%20proteins%20induced%20by%20NTAPP.%20Furthermore%2C%20we%20observed%20that%20NTAPP%20induced%20the%20activation%20of%20%5Cu03b2-catenin%20in%20DP%20cells%20of%20hair%20follicles%20and%20the%20mRNA%20levels%20of%20target%20genes%20of%20the%20%5Cu03b2-catenin%20signaling%20pathway%20%28CCND1%2C%20LEF1%2C%20and%20TCF4%29.%20NTAPP-treated%20mice%20exhibited%20markedly%20increased%20anagen%20induction%2C%20hair%20growth%2C%20and%20the%20protein%20levels%20of%20%5Cu03b2-catenin%2C%20p-GSK3%5Cu03b2%2C%20p-AKT%2C%20and%20cyclin%20D1.%20NTAPP%20stimulates%20hair%20growth%20via%20activation%20of%20the%20Wnt%5C%2F%5Cu03b2-catenin%20signaling%20pathway%20in%20DP%20cells.%20These%20findings%20collectively%20suggest%20that%20NTAPP%20may%20be%20a%20potentially%20safe%20and%20non-pharmacological%20therapeutic%20intervention%20for%20alopecia.%22%2C%22date%22%3A%222021-08-09%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-021-95650-y%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-021-95650-y%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-08-09T17%3A20%3A25Z%22%7D%7D%5D%7D
Hwang, J.-H., Lee, H.-Y., Chung, K. B., Lee, H. J., Kim, J., Song, K., & Kim, D.-Y. (2021). Non-thermal atmospheric pressure plasma activates Wnt/β-catenin signaling in dermal papilla cells. Scientific Reports, 11(1), 16125. https://doi.org/10.1038/s41598-021-95650-y Cite
