iPSC-Derived Neoantigen-Specific Cytotoxic T-Lymphocyte Therapy for Ewing Sarcoma

Investigators examined the antitumor effects of EWS/FLI1-rejTs against Ewing sarcoma. The altered amino acid sequence at the break/fusion point of EWS/FLI1, when presented as a neoantigen, evokes an immune response that targets EWS/FLI1+ sarcoma. examined the antitumor effects of EWS/FLI1-rejTs against Ewing sarcoma.