Scientists investigated whether and how factors that modulate T cell responsiveness to antigenic stimuli influence PD-1 function.
[Proceedings of the National Academy of Sciences of the United States of America]
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Shimizu, K., Sugiura, D., Okazaki, I., Maruhashi, T., Takemoto, T., & Okazaki, T. (2021). PD-1 preferentially inhibits the activation of low-affinity T cells. Proceedings of the National Academy of Sciences, 118(35). https://doi.org/10.1073/pnas.2107141118 Cite