Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsOne therapeutic approach showing a ray of hope to combat COVID-19 infection is MSC therapy. Mesenchymal cells have immunomodulatory, anti-inflammatory as well as regenerative properties and various preliminary studies have shown that MSCs can reverse the lung damage and overcome the cytokine storm incited by COVID-19 infection.
[Life Sciences]
6445212 MRQWDRNK items 1 apa 0 default asc 1 166292 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-d3d0246a5835d82d49cd128e1f7095f0%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22MRQWDRNK%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Pal%20et%20al.%22%2C%22parsedDate%22%3A%222021-11-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EPal%2C%20D.%2C%20Goyal%2C%20J.%2C%20Sharma%2C%20U.%2C%20Sharma%2C%20A.%2C%20Prashar%2C%20S.%2C%20Rathi%2C%20G.%2C%20Sharma%2C%20B.%2C%20%26amp%3B%20Kumar%2C%20U.%20%282021%29.%20Mesenchymal%20stem%20cells%20in%20SARS-CoV-2%20infection%3A%20A%20hype%20or%20hope.%20%3Ci%3ELife%20Sciences%3C%5C%2Fi%3E%2C%20%3Ci%3E284%3C%5C%2Fi%3E%2C%20119901.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.lfs.2021.119901%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.lfs.2021.119901%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3DMRQWDRNK%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Mesenchymal%20stem%20cells%20in%20SARS-CoV-2%20infection%3A%20A%20hype%20or%20hope%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Deeksha%22%2C%22lastName%22%3A%22Pal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jyoti%22%2C%22lastName%22%3A%22Goyal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ujjawal%22%2C%22lastName%22%3A%22Sharma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aman%22%2C%22lastName%22%3A%22Sharma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Saurabh%22%2C%22lastName%22%3A%22Prashar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Garima%22%2C%22lastName%22%3A%22Rathi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bunty%22%2C%22lastName%22%3A%22Sharma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Umesh%22%2C%22lastName%22%3A%22Kumar%22%7D%5D%2C%22abstractNote%22%3A%22COVID-19%20is%20a%20serious%20viral%20infection%20that%20struck%20the%20world%20in%20December%202019%20starting%20from%20Wuhan%20in%20China%2C%20spreading%20subsequently%20to%20all%20over%20the%20world.%20The%20disease%20has%20baffled%20scientists%20and%20doctors%20worldwide%20in%20terms%20of%20its%20presentation%2C%20behaviour%2C%20and%20treatment%20options%20till%20now.%20A%20low%20mortality%20rate%20is%20the%20only%20relief%20we%20get%20so%20far%20from%20COVID-19%20in%20terms%20of%20numbers.%20Treatment%20options%20have%20gradually%20streamlined%20to%20steroids%20and%20very%20few%20FDA%20approved%20antiviral%20as%20well%20as%20plasma%20therapy%20and%20supportive%20treatment.%20Monoclonal%20antibodies%20are%20used%20to%20tide%20over%20any%20impending%20cytokine%20storm%20but%20are%20not%20equally%20effective%20in%20all%20patients.%20Ventilation%20support%20is%20invariably%20required%20for%20moderate%20to%20severe%20disease%20varying%20from%20a%20simple%20High%20Flow%20non-rebreathing%20mask%20to%20BiPAP%20%28Bilevel%20Positive%20Airway%20Pressure%29%20and%20HFNO%20%28High-Flow%20Nasal%20Oxygen%29%20extending%20to%20full-fledge%20ventilation%20via%20a%20Mechanical%20Ventilator.%20Because%20of%20the%20non-availability%20of%20satisfactory%20treatment%20so%20far%2C%20many%20researchers%20from%20different%20biomedical%20fields%20are%20looking%20for%20alternative%20therapeutic%20strategies%20to%20manage%20the%20pandemic.%20One%20such%20therapeutic%20approach%20showing%20a%20ray%20of%20hope%20to%20combat%20COVID-19%20infection%20is%20Mesenchymal%20stem%20cell%20therapy.%20Mesenchymal%20cells%20have%20immunomodulatory%2C%20anti-inflammatory%20as%20well%20as%20regenerative%20properties%20and%20various%20preliminary%20studies%20have%20shown%20that%20MSCs%20can%20reverse%20the%20lung%20damage%20and%20overcome%20the%20cytokine%20storm%20incited%20by%20COVID-19%20infection.%20Also%2C%20it%20has%20improved%20the%20recovery%20rate%20of%20critically%20ill%20patients%20on%20mechanical%20ventilation.%20In%20this%20review%2C%20we%20will%20discuss%20the%20possibility%20and%20relevance%20of%20MSCs%20in%20COVID-19%20treatment%20and%20preview%20of%20various%20MSCs%20clinical%20trials.%22%2C%22date%22%3A%22November%201%2C%202021%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.lfs.2021.119901%22%2C%22ISSN%22%3A%220024-3205%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0024320521008882%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-08-31T17%3A01%3A04Z%22%7D%7D%5D%7D
Pal, D., Goyal, J., Sharma, U., Sharma, A., Prashar, S., Rathi, G., Sharma, B., & Kumar, U. (2021). Mesenchymal stem cells in SARS-CoV-2 infection: A hype or hope. Life Sciences, 284, 119901. https://doi.org/10.1016/j.lfs.2021.119901 Cite
