Oncostatin M Regulates Hematopoietic Stem Cell (HSC) Niches in the Bone Marrow to Restrict HSC Mobilization

Researchers showed that pro-inflammatory oncostatin M (OSM) was an important regulator of HSC niches in the bone marrow (BM). OSM up-regulated E-selectin expression on BM endothelial cells indirectly increasing HSC proliferation.