A Direct Negative Feedback Loop of miR-4721/FOXA1/Nanog Promotes Nasopharyngeal Cell Stem Cell Enrichment and Metastasis

In vivo and in vitro metastasis assays confirmed miR-4721 promoted cell migration and invasion. Tumor spheroid formation assay, side population assay, and ALDEFLUOR assay verified miR-4721 regulated cancer stem cell-like properties.