KARATE: PKA-Induced KRAS4B-RHOA-mTORC2 Supercomplex Phosphorylates AKT in Insulin Signaling and Glucose Homeostasis

By investigating insulin receptor signaling in human cells and biochemical reconstitution, scientists found that insulin induced the activation of mTORC2 toward AKT by assembling a supercomplex with KRAS4B and RHOA GTPases, termed KARATE (KRAS4B-RHOA-mTORC2 Ensemble).