ZBTB20 Regulates Plasma Triglyceride Metabolism by Repressing Lipoprotein Lipase Gene Transcription in Hepatocytes

Hepatocyte-specific inactivation of ZBTB20 in mice led to a remarkable increase in lipoprotein lipase (LPL) expression at the mRNA and protein levels in adult liver, in which LPL protein was mainly localized onto sinusoidal epithelial cells and Kupffer cells.