Comparison of the Blood, Bone Marrow, and Cerebrospinal Fluid Metabolomes in Children with B Cell Acute Lymphoblastic Leukemia

Researchers profiled end-induction plasma, marrow, and cerebrospinal fluid (CSF) from ten children with b-cell acute lymphoblastic leukemia using liquid chromatography-mass spectrometry and observed plasma-marrow correlations for metabolites in pathways associated with end-induction residual disease and plasma-CSF correlations for a biomarker of fatigue.