Emergence of β1 Integrin-Deficient Breast Tumors from Dormancy Involves Both Inactivation of p53 and Generation of a Permissive Tumor Microenvironment

Researchers reported that mammary epithelial-specific disruption of β1 integrin in a murine model of Luminal B human breast cancer drastically impaired tumor growth with proliferation block, apoptosis induction and cellular senescence.