Smoking-Associated Upregulation of CBX3 Suppresses ARHGAP24 Expression to Activate Rac1 Signaling and Promote Tumor Progression in Lung Adenocarcinoma

Scientists explored the mechanisms regulating histone methylation in lung adenocarcinoma (LUAD) in response to smoking. They found that the histone H3K9 methylation reader CBX3 was upregulated in current smokers with LUAD, and that CBX3 overexpression promoted LUAD progression.