Melittin and Diclofenac Synergistically Promote Wound Healing in a Pathway Involving TGF-β1

Melittin (MEL)-diclofenac (DCL) nano-complexes exhibited better regenerated epithelium, keratinization, epidermal proliferation, and granulation tissue formation and better wound healing activity than controls. Treatment of wounded skin with MEL-DCL nano-complexes showed an increase in mRNA expression levels of collagen.