Glucocorticoid Receptor Regulates PD-L1 and MHC-I in Pancreatic Cancer Cells to Promote Immune Evasion and Immunotherapy Resistance

Scientists demonstrated a previously undescribed tumor cell-intrinsic role for glucocorticoid receptor (GR) in activating PD-L1 expression and repressing the major histocompatibility complex class I expression in pancreatic ductal adenocarcinoma cells through transcriptional regulation.