NF-кB C-Rel Modulates Pre-Fibrotic Changes in Human Fibroblasts

In an in vitro model of fibrosis, investigators consistently observed the induction of the c-Rel subunit of NF-κB. Functional abrogation of c-Rel by siRNA resulted in diminished cell contractility of dermal fibroblasts in relaxed, but not in stressed 3D collagen matrices.