DRAM1 Increases the Secretion of PKM2-Enriched Extracellular Vesicles from Hepatocytes to Promote Macrophage Activation and Disease Progression in Alcohol-Related Liver Disease

The authors explored the expression, role and mechanism of DNA damage regulated autophagy modulator 1 (DRAM1) in alcohol-related liver disease and revealed that ethanol-induced DRAM1 of hepatic cells could increase the pyruvate kinase M2 (PKM2)-enriched extracellular vesicles.