AMPK-PERK Axis Represses Oxidative Metabolism and Enhances Apoptotic Priming of Mitochondria in Acute Myeloid Leukemia

Scientists found that selective AMP-activated protein kinase (AMPK)-activating compounds killed acute myeloid leukemia (AML) cells by rewiring mitochondrial metabolism that primed mitochondria to apoptosis by BH3 mimetics, holding therapeutic promise in AML.