TET2 Inactivation Restrains IL-10-Producing Regulatory B Cells to Enable Anti-Tumor Immunity in Hepatocellular Carcinoma

TET2 activation in B cells triggered by oxidative stress from the hepatocellular carcinoma (HCC) microenvironment promoted IL-10 expression, while the adoptive transfer of Tet2-deficient B cells suppressed HCC progression.