Calcineurin/NFATc2 and PI3K/AKT Signaling Maintains β-Cell Identity and Function during Metabolic and Inflammatory Stress

Scientists showed that intracellular Ca2+ and reactive oxygen species signals generated by high glucose and cytokine-induced endoplasmic reticulum stress activated calcineurin/NFATc2 and PI3K/AKT to maintain β-cell identity and function.