Glucose Limitation Activates AMPK Coupled SENP1-Sirt3 Signaling in Mitochondria for T Cell Memory Development

The authors provided evidence that the SUMO protease SENP1 promoted T cell memory development via Sirt3 deSUMOylation. SENP1-Sirt3 signaling augmented the deacetylase activity of Sirt3, promoting both OXPHOS and mitochondrial fusion.