Targeting miR-126 in inv(16) Acute Myeloid Leukemia Inhibits Leukemia Development and Leukemia Stem Cell Maintenance

The authors showed that miR-126 enhanced MYC activity through the SPRED1/PLK2-ERK-MYC axis. Genetic deletion of miR-126 significantly reduced acute myeloid leukemia rate and extended survival in CBFB-MYH11 knock-in mice.