Therapeutic Potential of Colchicine in Cardiovascular Medicine: A Pharmacological Review

The authors summarize the current clinical trials with proven curative effect of colchicine in treating cardiovascular diseases.
[Acta Pharmacologica Sinica]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Cell Therapy in Vascularized Composite Allotransplantation

Scientists discuss the recent works regarding the use of cell therapy to improve allograft outcomes.
[Biomedical Journal]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

CCN2-Induced Lymphangiogenesis Is Mediated by the Integrin αvβ5–ERK Pathway and Regulated by DUSP6

The authors found that communication network factor 2 (CCN2) induced phosphorylation of ERK in primary cultured lymphatic endothelial cells, which was almost completely inhibited by the blockade of integrin αvβ5 and partially decreased by the blockade of integrin αvβ3.
[Scientific Reports]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

The Endothelial Diapedesis Synapse Regulates Transcellular Migration of Human T Lymphocytes in a CX3CL1- and SNAP23-Dependent Manner

Investigators demonstrated that human central memory cytotoxic T lymphocytes (CTLs) crossed the endothelium in a predominantly paracellular fashion, whereas effector and effector memory CTLs crossed the endothelium preferably in a transcellular fashion.
[Cell Reports]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

Share

Thymosin Beta-4 Improves Endothelial Function and Reparative Potency of Diabetic Endothelial Cells Differentiated from Patient Induced Pluripotent Stem Cells

Scientists assessed the role of thymosin β-4 on endothelial function using diabetic human induced pluripotent stem cells derived endothelial cells as disease model of endothelial dysfunction.
[Stem Cell Research & Therapy]
[zotpress userid=’7992332′ items=’EEEEEEEE’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Angiogenesis Depends upon EPHB4-Mediated Export of Collagen IV from Vascular Endothelial Cells

The authors showed that induced endothelial cell (EC)-specific disruption of Ephb4 in mice resulted in accumulation of collagen IV in the EC endoplasmic reticulum leading to EC apoptotic death and defective developmental, neonatal and pathological angiogenesis.
[JCI Insight]
[zotpress userid=’7992332′ items=’CCCCCCCC’ style=’apa’ cite=’yes’]
AbstractFull Article
Bookmark

No account yet? Register

Share

Cysteine Oxidation of Copper Transporter CTR1 Drives VEGFR2 Signaling and Angiogenesis

Oxidation of CTR1 at Cys189 promoted VEGFR2 internalization and signaling to enhance angiogenesis. Scientists uncovered an important mechanism for sensing reactive oxygen species through CTR1 to drive neovascularization.
[Nature Cell Biology]
[zotpress userid=’7992332′ items=’EEEEEEEE’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Endothelial Thrombomodulin Downregulation Caused by Hypoxia Contributes to Severe Infiltration and Coagulopathy in COVID-19 Patient Lungs

Pulmonary endothelial cells become dysfunctional during COVID-19, showing a loss of thrombomodulin expression related to severe thrombosis and infiltration, and endothelial cell dysfunction might be caused by a pathologic condition in COVID-19 patient lungs rather than a direct infection with SARS-CoV-2.
[Ebiomedicine]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Eukaryotic Initiation Factor 6 Regulates Mechanical Responses in Endothelial Cells

Eukaryotic initiation factor 6 (eIF6)-depleted endothelial cells, under basal conditions, exhibit unchanged nascent protein synthesis, polysome profiles, and cytoskeleton protein expression. The authors showed that eIF6 was required for the correct spatial mechanoactivation of ERK1/2 via stabilization of an eIF6–RACK1–ERK1/2–FAK mechanocomplex
[Journal of Cell Biology]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Dapagliflozin Exerts Anti-inflammatory Effects via Inhibition of LPS-Induced TLR-4 Overexpression and NF-κB Activation in Human Endothelial Cells and Differentiated Macrophages

The authors assessed the direct anti-inflammatory effects of sodium-glucose co-transporter 2 inhibitors dapagliflozin on two cell types involved in the process of atherogenesis.
[European Journal of Pharmacology]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
AbstractGraphical Abstract
Bookmark

No account yet? Register

Share

AMIGO2 Contained in Cancer Cell-Derived Extracellular Vesicles Enhances the Adhesion of Liver Endothelial Cells to Cancer Cells

Scientists explored the role of cancer cell-derived amphoterin-induced gene and open reading frame 2 (AMIGO2)-containing extracellular vesicles in the adhesion of cancer cells to human hepatic sinusoidal endothelial cells.
[Scientific Reports]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share
Share