Elixir Medical announced that the first patient has been treated in the BIOADAPTOR randomized controlled trial of the DynamX™ Coronary Bioadaptor System, the first drug-eluting coronary artery implant that adapts to vessel physiology.
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Lymphatic marker-positive cells were present in the perivascular space, the walls of small and large arteries and veins, the media of large vessels along smooth muscle cell membranes, and the vascular adventitia.
[Proceedings of the National Academy of Sciences of the United States of America]
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Hyaluronan synthase 2 was strongly expressed in endothelial progenitor cells in the thickened intima. Moyamoya disease lesions showed minimal staining for chondroitin sulfate and hyaluronan in the endothelium, in contrast to control endothelium showing positive staining for both.
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Matsuo, M., Nadanaka, S., Soga, M., Sugiyama, T., Serigano, S., Shimano, K., Ichinose, F., Nakamura, T., Maeda, T., Houkin, K., Era, T., & Kitagawa, H. (2021). Vulnerability to shear stress caused by altered peri-endothelial matrix is a key feature of Moyamoya disease. Scientific Reports, 11(1), 1552. https://doi.org/10.1038/s41598-021-81282-9 Cite
Scientists examined the hypothesis that, during vascular remodeling after stroke, treatment with atorvastatin could facilitate blood-brain barrier maturation in remodeling vasculature in ischemic brain.
[Translational Stroke Research]
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Yang, Y., Yang, L. Y., Salayandia, V. M., Thompson, J. F., Torbey, M., & Yang, Y. (2021). Treatment with Atorvastatin During Vascular Remodeling Promotes Pericyte-Mediated Blood-Brain Barrier Maturation Following Ischemic Stroke. Translational Stroke Research. https://doi.org/10.1007/s12975-020-00883-0 Cite
Investigators tested whether fenofibrate, with its anti-inflammatory and vasoprotective effects, could improve myocardial function by activating endothelial progenitor cells through the eNOS pathway in a doxorubicin-induced cardiomyopathy mouse model.
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The authors investigated molecular mechanisms that altered the growth and metabolism of isolated lymphatic endothelial cells exposed to prolonged pathologically elevated lymph flow in vivo within the anatomic and physiologic context of a large animal model of congenital heart disease with increased pulmonary blood flow using in vitro approaches.
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Boehme, J. T., Morris, C. J., Chiacchia, S. R., Gong, W., Wu, K. Y., Kameny, R. J., Raff, G. W., Fineman, J. R., Maltepe, E., & Datar, S. A. (2021). HIF-1α promotes cellular growth in lymphatic endothelial cells exposed to chronically elevated pulmonary lymph flow. Scientific Reports, 11(1), 1468. https://doi.org/10.1038/s41598-020-80882-1 Cite
Researchers present a computational workflow that could identify transcription factors that were crucial for modulating pathways involved in cell lineage specification.
[Cell Death & Disease]
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De Smedt, J., van Os, E. A., Talon, I., Ghosh, S., Toprakhisar, B., Furtado Madeiro Da Costa, R., Zaunz, S., Vazquez, M. A., Boon, R., Baatsen, P., Smout, A., Verhulst, S., van Grunsven, L. A., & Verfaillie, C. M. (2021). PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells. Cell Death & Disease, 12(1), 1–18. https://doi.org/10.1038/s41419-020-03356-2 Cite
The authors performed an in silico study of ADAMTS1 and endothelial markers in human gliomas, providing the basis to further assess these molecules in several primary glioblastoma-initiating cells and established glioblastoma cells with the ability to acquire an endothelial-like phenotype.
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Investigators report a fucoidan-decorated silica-carbon nano-onion hybrid nanoparticle that targeted tumor vasculature to specifically release P-glycoprotein inhibitor and anticancer drug into tumor cells.
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Wang, H., Liang, Y., Yin, Y., Zhang, J., Su, W., White, A. M., Bin Jiang, Xu, J., Zhang, Y., Stewart, S., Lu, X., & He, X. (2021). Carbon nano-onion-mediated dual targeting of P-selectin and P-glycoprotein to overcome cancer drug resistance. Nature Communications, 12(1), 312. https://doi.org/10.1038/s41467-020-20588-0 Cite
The authors investigated changes of the vascular smooth muscle cell (VSMC) transcriptome by utilizing 3D human vascular organoids organized as a core of VSMCs enclosed by a monolayer of endothelial cells.
[Experimental Cell Research]
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The authors describe that the stemness and differentiation potential of cancer stem cells were enhanced under hypoxic microenvironments, through hypoxia-induced epithelial-endothelial transition and extracellular matrix remodeling to form the specific mechanism of vasculogenic mimicry.
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Wei, X., Chen, Y., Jiang, X., Peng, M., Liu, Y., Mo, Y., Ren, D., Hua, Y., Yu, B., Zhou, Y., Liao, Q., Wang, H., Xiang, B., Zhou, M., Li, X., Li, G., Li, Y., Xiong, W., & Zeng, Z. (2021). Mechanisms of vasculogenic mimicry in hypoxic tumor microenvironments. Molecular Cancer, 20(1), 7. https://doi.org/10.1186/s12943-020-01288-1 Cite