When GCSDL contacted with tumor vascular endothelial cells, the overexpressed γ‐glutamyltranspeptidase enzyme on cytomembrane catalyzed the hydrolysis of GSH to generate cationic primary amines.
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Mass spectrometry of endothelial cell culture media following P. aeruginosa infection allowed identification of multiple potential secreted modulators of beta amyloid, including cystatin C, gelsolin, and ApoJ/clusterin.
[Febs Open Bio]
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Balczon, R., Morrow, K. A., Leavesley, S., Francis, C. M., Stevens, T. C., Agwaramgbo, E., Williams, C., Stevens, R. P., Langham, G., Voth, S., Cioffi, E. A., Weintraub, S. E., & Stevens, T. (n.d.). Cystatin C regulates the cytotoxicity of infection-induced endothelial-derived β-amyloid. FEBS Open Bio, n/a(n/a). https://doi.org/10.1002/2211-5463.12997 Cite
To identify the active paracrine factors released by macrophages in response to stimulation by mesenchymal stem cell (MSC) conditioned media scientists used an antibody array; identifying increased expression of the angiogenesis-related proteins stromal cell-derived factor 1 and plasminogen activator inhibitor-1. Knockdown of either protein inhibited the ability of conditioned media derived from MSC paracrine factor stimulated macrophages to induce endothelial cell differentiation both in vitro and in vivo.
[American Journal of Physiology-Cell Physiology]
Tim-3 was overexpressed in vascular endothelial HMVECs and HUVECs and in vitro assays were used to determine that Tim-3 promoted cell proliferation, migration, invasion and tube formation through activating cyclin D1, Ras homolog gene family member A and vascular endothelial growth factor receptor 2.
Amphiphilic derivatives of poly-N-vinylpyrrolidone nanoparticles (Amph-PVP NPs) and fluorescently labeled Amph-PVP-based NPs, namely “PVP” NPs and “F”-NPs, were synthesized to study Amph-PVP NPs interactions with HMEC-1 endothelial cells.
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Berdiaki, A., Perisynaki, E., Stratidakis, A., Kulikov, P. P., Kuskov, A. N., Stivaktakis, P., Henrich-Noack, P., Luss, A. L., Shtilman, M. M., Tzanakakis, G. N., Tsatsakis, A., & Nikitovic, D. (2020). Assessment of Amphiphilic Poly-N-vinylpyrrolidone Nanoparticles’ Biocompatibility with Endothelial Cells in Vitro and Delivery of an Anti-Inflammatory Drug. Molecular Pharmaceutics. https://doi.org/10.1021/acs.molpharmaceut.0c00667 Cite
This review presents current evidence from human and animal studies on integrin structure and molecular signaling, with particular emphasis on signal transduction in infants.
Researchers examined the pro-angiogenic effect of N-NAM using human umbilical vein endothelial cells and the rat middle cerebral artery occlusion model of stroke.
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Kim, S.-W., Lee, H.-K., Seol, S.-I., Davaanyam, D., Lee, H., & Lee, J.-K. (2020). Ninjurin 1 dodecamer peptide containing the N-terminal adhesion motif (N-NAM) exerts proangiogenic effects in HUVECs and in the postischemic brain. Scientific Reports, 10(1), 16656. https://doi.org/10.1038/s41598-020-73340-5 Cite
The authors’ in vitro study indicated that high glucose increased monocyte/endothelial adhesion, endothelial adhesion molecule expression and p65 phosphorylation in human umbilical vein endothelial cells.
[Experimental and Molecular Medicine]
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Shen, X., Chen, X., Wang, J., Liu, J., Wang, Z., Hua, Q., Wu, Q., Su, Y., He, H., Hu, Y., Meng, Z., Xiong, W., & Zhu, M. (2020). SET8 suppression mediates high glucose-induced vascular endothelial inflammation via the upregulation of PTEN. Experimental & Molecular Medicine, 1–15. https://doi.org/10.1038/s12276-020-00509-3 Cite
In vivo studies showed that NOS inhibition strongly suppressed hind limb angiogenetic remodeling by impairing differentiation of endothelial cells and smooth muscle cells, and extracellular matrix synthesis.
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Wu, Z., Yao, H., Xu, H., Wang, Y., Hu, W., Lou, G., Zhang, L., Huang, C., Jiang, C., Zhou, S., Shi, Y., Chen, X., Yang, L., Xu, Y., & Wang, Y. (2020). Inhibition of eNOS by L-NAME resulting in rat hind limb developmental defects through PFKFB3 mediated angiogenetic pathway. Scientific Reports, 10(1), 16754. https://doi.org/10.1038/s41598-020-74011-1 Cite
Eyevensys announced the FDA has granted an orphan-drug designation for EYS611 for the treatment of retinitis pigmentosa.
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Scientists identified a novel circRNA, circ_2858, that was significantly upregulated in human brain microvascular endothelial cells upon meningitic E. coli infection.
[Molecular Therapy-Nucleic Acids]
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Yang, R., Chen, J., Xu, B., Yang, B., Fu, J., Xiao, S., Tan, C., Chen, H., & Wang, X. (2020). Circ_2858 helps blood-brain barrier disruption by increasing VEGFA via sponging miR-93-5p during Escherichia coli meningitis. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2020.09.034 Cite