International Trial to Compare Bioadaptor, a Novel Coronary Artery Implant Designed to Adapt to Vessel Physiology, with Traditional Drug Eluting Stents

Elixir Medical announced that the first patient has been treated in the BIOADAPTOR randomized controlled trial of the DynamX™ Coronary Bioadaptor System, the first drug-eluting coronary artery implant that adapts to vessel physiology.
[Elixir Medical]
Press Release
Bookmark

No account yet? Register

0
Share

An Immunohistochemical Study of Lymphatic Elements in the Human Brain

Lymphatic marker-positive cells were present in the perivascular space, the walls of small and large arteries and veins, the media of large vessels along smooth muscle cell membranes, and the vascular adventitia.
[Proceedings of the National Academy of Sciences of the United States of America]
Mezey, É., Szalayova, I., Hogden, C. T., Brady, A., Dósa, Á., Sótonyi, P., & Palkovits, M. (2021). An immunohistochemical study of lymphatic elements in the human brain. Proceedings of the National Academy of Sciences, 118(3). https://doi.org/10.1073/pnas.2002574118 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Vulnerability to Shear Stress Caused by Altered Peri-Endothelial Matrix Is a Key Feature of Moyamoya Disease

Hyaluronan synthase 2 was strongly expressed in endothelial progenitor cells in the thickened intima. Moyamoya disease lesions showed minimal staining for chondroitin sulfate and hyaluronan in the endothelium, in contrast to control endothelium showing positive staining for both.
[Scientific Reports]
Matsuo, M., Nadanaka, S., Soga, M., Sugiyama, T., Serigano, S., Shimano, K., Ichinose, F., Nakamura, T., Maeda, T., Houkin, K., Era, T., & Kitagawa, H. (2021). Vulnerability to shear stress caused by altered peri-endothelial matrix is a key feature of Moyamoya disease. Scientific Reports, 11(1), 1552. https://doi.org/10.1038/s41598-021-81282-9 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Treatment with Atorvastatin During Vascular Remodeling Promotes Pericyte-Mediated Blood-Brain Barrier Maturation Following Ischemic Stroke

Scientists examined the hypothesis that, during vascular remodeling after stroke, treatment with atorvastatin could facilitate blood-brain barrier maturation in remodeling vasculature in ischemic brain.
[Translational Stroke Research]
Yang, Y., Yang, L. Y., Salayandia, V. M., Thompson, J. F., Torbey, M., & Yang, Y. (2021). Treatment with Atorvastatin During Vascular Remodeling Promotes Pericyte-Mediated Blood-Brain Barrier Maturation Following Ischemic Stroke. Translational Stroke Research. https://doi.org/10.1007/s12975-020-00883-0 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Fenofibrate Attenuates Doxorubicin-Induced Cardiac Dysfunction in Mice via Activating the eNOS/EPC Pathway

Investigators tested whether fenofibrate, with its anti-inflammatory and vasoprotective effects, could improve myocardial function by activating endothelial progenitor cells through the eNOS pathway in a doxorubicin-induced cardiomyopathy mouse model.
[Scientific Reports]
Huang, W.-P., Yin, W.-H., Chen, J.-S., Huang, P.-H., Chen, J.-W., & Lin, S.-J. (2021). Fenofibrate attenuates doxorubicin-induced cardiac dysfunction in mice via activating the eNOS/EPC pathway. Scientific Reports, 11(1), 1159. https://doi.org/10.1038/s41598-021-80984-4 Cite
Full Article
Bookmark

No account yet? Register

0
Share

HIF-1α Promotes Cellular Growth in Lymphatic Endothelial Cells Exposed to Chronically Elevated Pulmonary Lymph Flow

The authors investigated molecular mechanisms that altered the growth and metabolism of isolated lymphatic endothelial cells exposed to prolonged pathologically elevated lymph flow in vivo within the anatomic and physiologic context of a large animal model of congenital heart disease with increased pulmonary blood flow using in vitro approaches.
[Scientific Reports]
Boehme, J. T., Morris, C. J., Chiacchia, S. R., Gong, W., Wu, K. Y., Kameny, R. J., Raff, G. W., Fineman, J. R., Maltepe, E., & Datar, S. A. (2021). HIF-1α promotes cellular growth in lymphatic endothelial cells exposed to chronically elevated pulmonary lymph flow. Scientific Reports, 11(1), 1468. https://doi.org/10.1038/s41598-020-80882-1 Cite
Full Article
Bookmark

No account yet? Register

0
Share

PU.1 Drives Specification of Pluripotent Stem Cell-Derived Endothelial Cells to LSEC-Like Cells

Researchers present a computational workflow that could identify transcription factors that were crucial for modulating pathways involved in cell lineage specification.
[Cell Death & Disease]
De Smedt, J., van Os, E. A., Talon, I., Ghosh, S., Toprakhisar, B., Furtado Madeiro Da Costa, R., Zaunz, S., Vazquez, M. A., Boon, R., Baatsen, P., Smout, A., Verhulst, S., van Grunsven, L. A., & Verfaillie, C. M. (2021). PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells. Cell Death & Disease, 12(1), 1–18. https://doi.org/10.1038/s41419-020-03356-2 Cite
Full Article
Bookmark

No account yet? Register

0
Share

ADAMTS1 Supports Endothelial Plasticity of Glioblastoma Cells with Relevance for Glioma Progression

The authors performed an in silico study of ADAMTS1 and endothelial markers in human gliomas, providing the basis to further assess these molecules in several primary glioblastoma-initiating cells and established glioblastoma cells with the ability to acquire an endothelial-like phenotype.
[Biomolecules]
Full Article
Bookmark

No account yet? Register

0
Share

Carbon Nano-Onion-Mediated Dual Targeting of P-Selectin and P-Glycoprotein to Overcome Cancer Drug Resistance

Investigators report a fucoidan-decorated silica-carbon nano-onion hybrid nanoparticle that targeted tumor vasculature to specifically release P-glycoprotein inhibitor and anticancer drug into tumor cells.
[Nature Communications]
Wang, H., Liang, Y., Yin, Y., Zhang, J., Su, W., White, A. M., Bin Jiang, Xu, J., Zhang, Y., Stewart, S., Lu, X., & He, X. (2021). Carbon nano-onion-mediated dual targeting of P-selectin and P-glycoprotein to overcome cancer drug resistance. Nature Communications, 12(1), 312. https://doi.org/10.1038/s41467-020-20588-0 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Endothelial Cells Control Vascular Smooth Muscle Cell Cholesterol Levels by Regulating 24-Dehydrocholesterol Reductase Expression

The authors investigated changes of the vascular smooth muscle cell (VSMC) transcriptome by utilizing 3D human vascular organoids organized as a core of VSMCs enclosed by a monolayer of endothelial cells.
[Experimental Cell Research]
Kohlhaas, J., Jäger, M., Lust, L., De La Torre, C., Hecker, M., & Korff, T. (2021). Endothelial cells control vascular smooth muscle cell cholesterol levels by regulating 24-dehydrocholesterol reductase expression. Experimental Cell Research, 112446. https://doi.org/10.1016/j.yexcr.2020.112446 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Mechanisms of Vasculogenic Mimicry in Hypoxic Tumor Microenvironments

The authors describe that the stemness and differentiation potential of cancer stem cells were enhanced under hypoxic microenvironments, through hypoxia-induced epithelial-endothelial transition and extracellular matrix remodeling to form the specific mechanism of vasculogenic mimicry.
[Molecular Cancer]
Wei, X., Chen, Y., Jiang, X., Peng, M., Liu, Y., Mo, Y., Ren, D., Hua, Y., Yu, B., Zhou, Y., Liao, Q., Wang, H., Xiang, B., Zhou, M., Li, X., Li, G., Li, Y., Xiong, W., & Zeng, Z. (2021). Mechanisms of vasculogenic mimicry in hypoxic tumor microenvironments. Molecular Cancer, 20(1), 7. https://doi.org/10.1186/s12943-020-01288-1 Cite
Full Article
Bookmark

No account yet? Register

0
Share
Share