Visceral Obesity and Insulin Resistance Associate with CD36 Deletion in Lymphatic Endothelial Cells

Investigators showed that that intestinal lymphatic endothelial cells (LECs) have an increasing CD36 expression from lymphatic capillaries to collecting vessels, and that LEC CD36 regulated lymphatic integrity and optimized lipid transport.
[Nature Communications]
Cifarelli, V., Appak-Baskoy, S., Peche, V. S., Kluzak, A., Shew, T., Narendran, R., Pietka, K. M., Cella, M., Walls, C. W., Czepielewski, R., Ivanov, S., Randolph, G. J., Augustin, H. G., & Abumrad, N. A. (2021). Visceral obesity and insulin resistance associate with CD36 deletion in lymphatic endothelial cells. Nature Communications, 12(1), 3350. https://doi.org/10.1038/s41467-021-23808-3 Cite
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The C5a/C5a Receptor 1 Axis Controls Tissue Neovascularization through CXCL4 Release from Platelets

The authors showed that platelets expressing C5aR1 exert an inhibitory effect on endothelial cell functions such as migration and 2D and 3D tube formation.
[Nature Communications]
Nording, H., Baron, L., Haberthür, D., Emschermann, F., Mezger, M., Sauter, M., Sauter, R., Patzelt, J., Knoepp, K., Nording, A., Meusel, M., Meyer-Saraei, R., Hlushchuk, R., Sedding, D., Borst, O., Eitel, I., Karsten, C. M., Feil, R., Pichler, B., … Langer, H. F. (2021). The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets. Nature Communications, 12(1), 3352. https://doi.org/10.1038/s41467-021-23499-w Cite
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Is the Endothelium the Missing Link in the Pathophysiology and Treatment of COVID-19 Complications?

The clinical features of COVID-19, the central role of the endothelium in COVID-19 and in other pathologies, and the potential of specific therapies aimed at protecting the endothelium in COVID-19 patients are addressed.
[Cardiovascular Drugs and Therapy]
Castro, P., Palomo, M., Moreno-Castaño, A. B., Fernández, S., Torramadé-Moix, S., Pascual, G., Martinez-Sanchez, J., Richardson, E., Téllez, A., Nicolas, J. M., Carreras, E., Richardson, P. G., Badimon, J. J., Escolar, G., & Diaz-Ricart, M. (2021). Is the Endothelium the Missing Link in the Pathophysiology and Treatment of COVID-19 Complications? Cardiovascular Drugs and Therapy. https://doi.org/10.1007/s10557-021-07207-w Cite
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Endothelial-Derived Cardiovascular Disease-Related microRNAs Elevated with Prolonged Sitting Pattern among Postmenopausal Women

Researchers explored the association between sitting patterns and microRNAs isolated from endothelial cell-derived extracellular vesicles.
[Scientific Reports]
Chang, Y.-J., Tuz-Zahra, F., Godbole, S., Avitia, Y., Bellettiere, J., Rock, C. L., Jankowska, M. M., Allison, M. A., Dunstan, D. W., Rana, B., Natarajan, L., & Sears, D. D. (2021). Endothelial-derived cardiovascular disease-related microRNAs elevated with prolonged sitting pattern among postmenopausal women. Scientific Reports, 11(1), 11766. https://doi.org/10.1038/s41598-021-90154-1 Cite
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Gelatin Methacryloyl Hydrogels Functionalized with Endothelin-1 for Angiogenesis and Full-Thickness Wound Healing

The endothelin-1 in the functional hydrogels significantly promoted the proliferation, migration and angiogenesis-related gene expression of human umbilical vein endothelial cells and fibroblasts.
[Journal of Materials Chemistry B]
Li, M.-N., Yu, H.-P., Ke, Q.-F., Zhang, C.-Q., Gao, Y.-S., & Guo, Y.-P. (2021). Gelatin methacryloyl hydrogels functionalized with endothelin-1 for angiogenesis and full-thickness wound healing. Journal of Materials Chemistry B. https://doi.org/10.1039/D1TB00449B Cite
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Cancer-Secreted Exosomal miR-21-5p Induces Angiogenesis and Vascular Permeability by Targeting KRIT1

Researchers showed the delivery of miR-21-5p from colorectal cancer (CRC) cells to endothelial cells via exosomes increased the amount of miR-21-5p in recipient cells, suggesting that exosomal miR-21-5p was involved in angiogenesis and vascular permeability in CRC.
[Cell Death & Disease]
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Effects of Vitamin D-Induced Supernatant of Placental Explants from Preeclamptic Women on Oxidative Stress and Nitric Oxide Bioavailability in Human Umbilical Vein Endothelial Cells

Scientists evaluated the effect of the supernatant of placental explants from preeclamptic and normotensive pregnant women after tissue treatment with or without vitamin D on oxidative stress and nitric oxide bioavailability in human umbilical vein endothelial cells
[Brazilian Journal of Medical and Biological Research]
Nunes, P. R., Gomes, V. J., Sandrim, V. C., Peraçoli, J. C., Peraçoli, M. T. S., & Carlström, M. (2021). Effects of vitamin D-induced supernatant of placental explants from preeclamptic women on oxidative stress and nitric oxide bioavailability in human umbilical vein endothelial cells. Brazilian Journal of Medical and Biological Research, 54. https://doi.org/10.1590/1414-431X2020e11073 Cite
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Sulodexide Reduces Glucose Induced Senescence in Human Retinal Endothelial Cells

Scientists evaluated the effect of high glucose concentration on senescence in human retinal endothelial cells and modulation of that effect by Sulodexide.
[Scientific Reports]
Gericke, A., Suminska-Jasińska, K., & Bręborowicz, A. (2021). Sulodexide reduces glucose induced senescence in human retinal endothelial cells. Scientific Reports, 11(1), 11532. https://doi.org/10.1038/s41598-021-90987-w Cite
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Zinc Drives Vasorelaxation by Acting in Sensory Nerves, Endothelium and Smooth Muscle

Researchers found that elevating cytoplasmic zinc using ionophores relaxed rat and human isolated blood vessels and caused hyperpolarization of smooth muscle membrane.
[Nature Communications]
Betrie, A. H., Brock, J. A., Harraz, O. F., Bush, A. I., He, G.-W., Nelson, M. T., Angus, J. A., Wright, C. E., & Ayton, S. (2021). Zinc drives vasorelaxation by acting in sensory nerves, endothelium and smooth muscle. Nature Communications, 12(1), 3296. https://doi.org/10.1038/s41467-021-23198-6 Cite
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3D Cell Culture Using a Clinostat Reproduces Microgravity-Induced Skin Changes

Investigators showed that under time-averaged simulated microgravity, the thickness of the endothelial cell arrangement increased by up to 59.75%, indicating skin irritation due to vasodilation, and that the diameter of keratinocytes and fibroblast co-cultured spheroids decreased by 6.66%, representing skin thinning.
[npj Microgravity]
Choi, D. H., Jeon, B., Lim, M. H., Lee, D. H., Ye, S.-K., Jeong, S.-Y., & Kim, S. (2021). 3D cell culture using a clinostat reproduces microgravity-induced skin changes. Npj Microgravity, 7(1), 1–7. https://doi.org/10.1038/s41526-021-00148-6 Cite
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Heparan Sulfate Proteoglycan Glypican-1 and PECAM-1 Cooperate in Shear-Induced Endothelial Nitric Oxide Production

Atomic force microscopy pulling was used to apply force to glypican-1 and PECAM-1 on the surface of human umbilical vein endothelial cells and nitric oxide was measured using a fluorescent reporter dye.
[Scientific Reports]
Bartosch, A. M. W., Mathews, R., Mahmoud, M. M., Cancel, L. M., Haq, Z. S., & Tarbell, J. M. (2021). Heparan sulfate proteoglycan glypican-1 and PECAM-1 cooperate in shear-induced endothelial nitric oxide production. Scientific Reports, 11(1), 11386. https://doi.org/10.1038/s41598-021-90941-w Cite
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