Active Transportation of Liposome Enhances Tumor Accumulation, Penetration, and Therapeutic Efficacy

When GCSDL contacted with tumor vascular endothelial cells, the overexpressed γ‐glutamyltranspeptidase enzyme on cytomembrane catalyzed the hydrolysis of GSH to generate cationic primary amines.
[Small]
Wang, G., Wu, B., Li, Q., Chen, S., Jin, X., Liu, Y., Zhou, Z., Shen, Y., & Huang, P. (n.d.). Active Transportation of Liposome Enhances Tumor Accumulation, Penetration, and Therapeutic Efficacy. Small, n/a(n/a), 2004172. https://doi.org/10.1002/smll.202004172 Cite
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Cystatin C Regulates the Cytotoxicity of Infection‐Induced Endothelial‐Derived β‐Amyloid

Mass spectrometry of endothelial cell culture media following P. aeruginosa infection allowed identification of multiple potential secreted modulators of beta amyloid, including cystatin C, gelsolin, and ApoJ/clusterin.
[Febs Open Bio]
Balczon, R., Morrow, K. A., Leavesley, S., Francis, C. M., Stevens, T. C., Agwaramgbo, E., Williams, C., Stevens, R. P., Langham, G., Voth, S., Cioffi, E. A., Weintraub, S. E., & Stevens, T. (n.d.). Cystatin C regulates the cytotoxicity of infection-induced endothelial-derived β-amyloid. FEBS Open Bio, n/a(n/a). https://doi.org/10.1002/2211-5463.12997 Cite
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Sequential Paracrine Mechanisms Are Necessary for the Therapeutic Benefits of Stem Cell Therapy

To identify the active paracrine factors released by macrophages in response to stimulation by mesenchymal stem cell (MSC) conditioned media scientists used an antibody array; identifying increased expression of the angiogenesis-related proteins stromal cell-derived factor 1 and plasminogen activator inhibitor-1. Knockdown of either protein inhibited the ability of conditioned media derived from MSC paracrine factor stimulated macrophages to induce endothelial cell differentiation both in vitro and in vivo.
[American Journal of Physiology-Cell Physiology]
Sun, H., Pratt, R. E., Hodgkinson, C. P., & Dzau, V. J. (2020). Sequential paracrine mechanisms are necessary for the therapeutic benefits of stem cell therapy. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.00516.2019 Cite
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Tim-3 Promotes Tube Formation and Decreases Tight Junction Formation in Vascular Endothelial Cells

Tim-3 was overexpressed in vascular endothelial HMVECs and HUVECs and in vitro assays were used to determine that Tim-3 promoted cell proliferation, migration, invasion and tube formation through activating cyclin D1, Ras homolog gene family member A and vascular endothelial growth factor receptor 2.
[Bioscience Reports]
Cong, Y., Wang, X., Wang, S., Qiao, G., Li, Y., Cao, J., Jiang, W. G., & Cui, Y. (n.d.). Tim-3 promotes tube formation and decreases tight junction formation in vascular endothelial cells. Bioscience Reports. https://doi.org/10.1042/BSR20202130 Cite
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Assessment of Amphiphilic Poly-N-vinylpyrrolidone Nanoparticles’ Biocompatibility with Endothelial Cells In Vitro and Delivery of an Anti-Inflammatory Drug

Amphiphilic derivatives of poly-N-vinylpyrrolidone nanoparticles (Amph-PVP NPs) and fluorescently labeled Amph-PVP-based NPs, namely “PVP” NPs and “F”-NPs, were synthesized to study Amph-PVP NPs interactions with HMEC-1 endothelial cells.
[Molecular Pharmaceutics]
Berdiaki, A., Perisynaki, E., Stratidakis, A., Kulikov, P. P., Kuskov, A. N., Stivaktakis, P., Henrich-Noack, P., Luss, A. L., Shtilman, M. M., Tzanakakis, G. N., Tsatsakis, A., & Nikitovic, D. (2020). Assessment of Amphiphilic Poly-N-vinylpyrrolidone Nanoparticles’ Biocompatibility with Endothelial Cells in Vitro and Delivery of an Anti-Inflammatory Drug. Molecular Pharmaceutics. https://doi.org/10.1021/acs.molpharmaceut.0c00667 Cite
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The Role of Integrins in Inflammation and Angiogenesis

This review presents current evidence from human and animal studies on integrin structure and molecular signaling, with particular emphasis on signal transduction in infants.
[Pediatric Research]
Mezu-Ndubuisi, O. J., & Maheshwari, A. (2020). The role of integrins in inflammation and angiogenesis. Pediatric Research, 1–9. https://doi.org/10.1038/s41390-020-01177-9 Cite
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Ninjurin 1 Dodecamer Peptide Containing the N-Terminal Adhesion Motif (N-NAM) Exerts Proangiogenic Effects in HUVECs and in the Postischemic Brain

Researchers examined the pro-angiogenic effect of N-NAM using human umbilical vein endothelial cells and the rat middle cerebral artery occlusion model of stroke.
[Scientific Reports]
Kim, S.-W., Lee, H.-K., Seol, S.-I., Davaanyam, D., Lee, H., & Lee, J.-K. (2020). Ninjurin 1 dodecamer peptide containing the N-terminal adhesion motif (N-NAM) exerts proangiogenic effects in HUVECs and in the postischemic brain. Scientific Reports, 10(1), 16656. https://doi.org/10.1038/s41598-020-73340-5 Cite
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SET8 Suppression Mediates High Glucose-Induced Vascular Endothelial Inflammation via the Upregulation of PTEN

The authors’ in vitro study indicated that high glucose increased monocyte/endothelial adhesion, endothelial adhesion molecule expression and p65 phosphorylation in human umbilical vein endothelial cells.
[Experimental and Molecular Medicine]
Shen, X., Chen, X., Wang, J., Liu, J., Wang, Z., Hua, Q., Wu, Q., Su, Y., He, H., Hu, Y., Meng, Z., Xiong, W., & Zhu, M. (2020). SET8 suppression mediates high glucose-induced vascular endothelial inflammation via the upregulation of PTEN. Experimental & Molecular Medicine, 1–15. https://doi.org/10.1038/s12276-020-00509-3 Cite
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Inhibition of eNOS by L-NAME Resulting in Rat Hind Limb Developmental Defects through PFKFB3 Mediated Angiogenetic Pathway

In vivo studies showed that NOS inhibition strongly suppressed hind limb angiogenetic remodeling by impairing differentiation of endothelial cells and smooth muscle cells, and extracellular matrix synthesis.
[Scientific Reports]
Wu, Z., Yao, H., Xu, H., Wang, Y., Hu, W., Lou, G., Zhang, L., Huang, C., Jiang, C., Zhou, S., Shi, Y., Chen, X., Yang, L., Xu, Y., & Wang, Y. (2020). Inhibition of eNOS by L-NAME resulting in rat hind limb developmental defects through PFKFB3 mediated angiogenetic pathway. Scientific Reports, 10(1), 16754. https://doi.org/10.1038/s41598-020-74011-1 Cite
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Eyevensys Receives FDA Orphan Drug Designation for EYS611 for Treatment of Retinitis Pigmentosa

Eyevensys announced the FDA has granted an orphan-drug designation for EYS611 for the treatment of retinitis pigmentosa.
[Eyevensys]
Press Release
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Circ_2858 Helps Blood-Brain Barrier Disruption by Increasing VEGFA via Sponging miR-93-5p during Escherichia coli Meningitis

Scientists identified a novel circRNA, circ_2858, that was significantly upregulated in human brain microvascular endothelial cells upon meningitic E. coli infection.
[Molecular Therapy-Nucleic Acids]
Yang, R., Chen, J., Xu, B., Yang, B., Fu, J., Xiao, S., Tan, C., Chen, H., & Wang, X. (2020). Circ_2858 helps blood-brain barrier disruption by increasing VEGFA via sponging miR-93-5p during Escherichia coli meningitis. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2020.09.034 Cite
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