Newsletters

[Advanced Science] Investigators identify Toll-interacting protein (TOLLIP) as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism.

[Science Advances] Researchers explored how extra-genetic factors, particularly metabolic and oxidative stress, influence Darier disease, showing that impaired antioxidant defenses can compromise SERCA2 function and weaken epidermal cell adhesion.

[Science Advances] Using unbiased transcriptomic, biochemical, and phosphoproteomic analyses, followed by targeted validation in human and mouse models, investigators found that fibroblast recognition of interleukin-1 is essential for immune response.

[Journal of Advanced Research] Scientists established a high-fidelity mouse skin organoid platform to simulate clinically relevant stressors and identify the core regulatory components of the regenerative program.

[Cell Death & Differentiation] The authors demonstrate that activation of β-catenin is associated with a poor prognosis in melanoma. This conclusion was based on immunohistochemical analysis of a cohort of 157 patients and the identification of a genetic signature for melanoma upon β-catenin activation.

[Biochimica Et Biophysica Acta-Molecular Cell Research] Researchers showed that melanoma cells resistant to BRAF (B-raf serine-threonine-protein kinase)/MEK (mitogen-activated protein kinase kinase)inhibitors undergo metabolic rewiring that supports a more invasive phenotype, linking therapy resistance with altered glycolysis, mitochondrial function, and lipid metabolism.

[Experimental Cell Research] Scientists highlight the contrasting roles of ferroptosis in vitiligo and melanoma, revealing shared mechanisms that could be exploited for melanocyte-specific therapeutic strategies.

[The University of British Columbia] UBC Faculty of Medicine researchers have been awarded more than $39 million in federal funding through the Canadian Institutes of Health Research (CIHR) Project Grant: Spring 2026 competition.

[Lupus Foundation of America] The Lupus Foundation of America announced the recipients of the 2026 Gary S. Gilkeson Career Development Award. The two-year grant supports early career scientists at a pivotal time in their professions, providing funding for critical research studies and mentorship to foster the growth of the lupus research field.

[Immunity] Researchers investigated whether melanocyte-intrinsic transcriptional program(s) underlie immune tolerance to mutations resulting from UV radiation exposure.

[Experimental & Molecular Medicine] Emerging evidence highlights the intricate interplay between metabolic reprogramming and epigenetic modifications in macrophages, neutrophils, and other innate immune populations within the tumor microenvironment.

[Journal of Allergy and Clinical Immunology] Investigators explored the effects of the IL-2 mutein Fc.mut24 on allergen-induced type 2 airway inflammation. Fc.mut24 therapy prevented allergic airway inflammation when delivered before type 2 effector T cell priming but was insufficient to overcome established allergen-specific type 2 responses.