The authors performed in vitro and in vivo experiments, six human IDH1/2 wild-type glioblastoma stem-like cells were established and studied to determine a potential interaction of YKL-40 and O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation.
[Cell Death & Disease]
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Chen, W., Zhang, X., Han, H., Lv, J., Kang, E., Zhang, Y., Liu, W., He, X., Wang, J., Wang, G., Yu, Y., & Zhang, W. (2020). The different role of YKL-40 in glioblastoma is a function of MGMT promoter methylation status. Cell Death & Disease, 11(8), 1–13. https://doi.org/10.1038/s41419-020-02909-9 Cite