CC-90009, a Novel Cereblon E3 Ligase Modulator Targets Acute Myeloid Leukemia Blasts and Leukemia Stem Cells

By
Justin.choi
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Using a genome-wide CRISPR-Cas9 screen for effectors of CC-90009 response, researchers uncovered the ILF2 and ILF3 heterodimeric complex as a novel regulator of cereblon expression. Knockout of ILF2/ILF3 decreased the production of full-length cereblon protein via modulating CRBN mRNA alternative splicing, leading to diminished response to CC-90009.
[Blood]
Surka, C., Jin, L., Mbong, N., Lu, C.-C., Jang, I. S., Rychak, E., Mendy, D., Clayton, T., Tindall, E. A., Hsu, C., Fontanillo, C., Tran, E., Contreras, A., Ng, S. W.-K., Matyskiela, M. E., Wang, K., Chamberlain, P. P., Cathers, B., Carmichael, J., … Lu, G. (n.d.). CC-90009, a novel cereblon E3 ligase modulator targets acute myeloid leukemia blasts and leukemia stem cells. Blood. https://doi.org/10.1182/blood.2020008676 Cite
Abstract