The authors explored how co-expression of progranulin and sortilin was associated with established clinical markers by analyzing a tissue microarray including 560 randomized premenopausal breast cancer patients receiving either two years of tamoxifen treatment or no adjuvant treatment, with a median follow-up time of 28 years.
[BMC Cancer]
6445212 {6445212:CGTDG6SV} apa 50 1 159401 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-f8b2b85ec735f28659f84619c7e30878%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22CGTDG6SV%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Berger%20et%20al.%22%2C%22parsedDate%22%3A%222021-02-22%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EBerger%2C%20K.%2C%20Rhost%2C%20S.%2C%20Rafnsd%26%23xF3%3Bttir%2C%20S.%2C%20Hughes%2C%20%26%23xC9%3B.%2C%20Magnusson%2C%20Y.%2C%20Ekholm%2C%20M.%2C%20St%26%23xE5%3Bl%2C%20O.%2C%20Ryd%26%23xE9%3Bn%2C%20L.%2C%20%26amp%3B%20Landberg%2C%20G.%20%282021%29.%20Tumor%20co-expression%20of%20progranulin%20and%20sortilin%20as%20a%20prognostic%20biomarker%20in%20breast%20cancer.%20%3Ci%3EBMC%20Cancer%3C%5C%2Fi%3E%2C%20%3Ci%3E21%3C%5C%2Fi%3E%281%29%2C%20185.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12885-021-07854-0%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12885-021-07854-0%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3DCGTDG6SV%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Tumor%20co-expression%20of%20progranulin%20and%20sortilin%20as%20a%20prognostic%20biomarker%20in%20breast%20cancer%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karoline%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sara%22%2C%22lastName%22%3A%22Rhost%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Svanhei%5Cu00f0ur%22%2C%22lastName%22%3A%22Rafnsd%5Cu00f3ttir%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22%5Cu00c9amon%22%2C%22lastName%22%3A%22Hughes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ylva%22%2C%22lastName%22%3A%22Magnusson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%22%2C%22lastName%22%3A%22Ekholm%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olle%22%2C%22lastName%22%3A%22St%5Cu00e5l%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lisa%22%2C%22lastName%22%3A%22Ryd%5Cu00e9n%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G%5Cu00f6ran%22%2C%22lastName%22%3A%22Landberg%22%7D%5D%2C%22abstractNote%22%3A%22The%20growth%20factor%20progranulin%20has%20been%20implicated%20in%20numerous%20biological%20processes%20such%20as%20wound%20healing%2C%20inflammation%20and%20progressive%20tumorigenesis.%20Both%20progranulin%20and%20its%20receptor%20sortilin%20are%20known%20to%20be%20highly%20expressed%20in%20subgroups%20of%20breast%20cancer%20and%20have%20been%20associated%20with%20various%20clinical%20properties%20including%20tamoxifen%20resistance.%20Recent%20data%20further%20suggest%20that%20progranulin%2C%20via%20its%20receptor%20sortilin%2C%20drives%20breast%20cancer%20stem%20cell%20propagation%20in%20vitro%20and%20increases%20metastasis%20formation%20in%20an%20in%20vivo%20breast%20cancer%20xenograft%20model.%20In%20this%20retrospective%20biomarker%20analysis%2C%20we%20aimed%20to%20determine%20whether%20tumor%20co-expression%20of%20progranulin%20and%20sortilin%20has%20prognostic%20and%20treatment%20predictive%20values%20for%20breast%20cancer%20patients.%22%2C%22date%22%3A%22February%2022%2C%202021%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12885-021-07854-0%22%2C%22ISSN%22%3A%221471-2407%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12885-021-07854-0%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-02-24T18%3A54%3A50Z%22%7D%7D%5D%7D
Berger, K., Rhost, S., Rafnsdóttir, S., Hughes, É., Magnusson, Y., Ekholm, M., Stål, O., Rydén, L., & Landberg, G. (2021). Tumor co-expression of progranulin and sortilin as a prognostic biomarker in breast cancer. BMC Cancer, 21(1), 185. https://doi.org/10.1186/s12885-021-07854-0 Cite